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    maea macrophage erythroblast attacher, E3 ubiquitin ligase [ Danio rerio (zebrafish) ]

    Gene ID: 321575, updated on 9-Dec-2024

    Summary

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    Official Symbol
    maeaprovided by ZNC
    Official Full Name
    macrophage erythroblast attacher, E3 ubiquitin ligaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-294
    See related
    Ensembl:ENSDARG00000053691 AllianceGenome:ZFIN:ZDB-GENE-030131-294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63708; wu:fb20a09
    Summary
    Predicted to enable actin binding activity; metal ion binding activity; and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cell division and erythrocyte maturation. Predicted to be located in nucleoplasm. Predicted to be part of GID complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAEA (macrophage erythroblast attacher, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See maea in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (21123867..21141068, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (20826622..20843823, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 20, E3 ubiquitin protein ligase Neighboring gene si:dkey-74k8.4 Neighboring gene aldolase b, fructose-bisphosphate Neighboring gene zgc:136929 Neighboring gene protein phosphatase 2, regulatory subunit B, gamma b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
    2. Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage-specific losses. Petit D, et al. Mol Biol Evol, 2015 Apr. PMID 25534026, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within erythrocyte maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein transferase MAEA
    NP_955843.2
    XP_021336639.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199549.2 → NP_955843.2  E3 ubiquitin-protein transferase MAEA

      Status: VALIDATED

      Source sequence(s)
      CT956093, EH435928
      UniProtKB/Swiss-Prot
      Q7SXR3
      Related
      ENSDARP00000070240.3, ENSDART00000075759.4
      Conserved Domains (5) summary
      smart00667
      Location:120 → 153
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:159 → 216
      CTLH; C-terminal to LisH motif
      smart00757
      Location:212 → 304
      CRA; CT11-RanBPM
      pfam10607
      Location:160 → 301
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      pfam13445
      Location:340 → 379
      zf-RING_UBOX; RING-type zinc-finger

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      21123867..21141068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480964.2 → XP_021336639.1  E3 ubiquitin-protein transferase MAEA isoform X1

      UniProtKB/TrEMBL
      A0A8M9QG98
      Conserved Domains (3) summary
      smart00667
      Location:111 → 144
      LisH; Lissencephaly type-1-like homology motif
      pfam10607
      Location:151 → 292
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cd16659
      Location:327 → 374
      RING-Ubox_Emp; U-box domain, a modified RING finger, found in erythroblast macrophage protein (Emp) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SXR3.2 GenPept UniProtKB/Swiss-Prot:Q7SXR3

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