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    vaspb vasodilator stimulated phosphoprotein b [ Danio rerio (zebrafish) ]

    Gene ID: 550487, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vaspbprovided by ZNC
    Official Full Name
    vasodilator stimulated phosphoprotein bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7118
    See related
    Ensembl:ENSDARG00000017105 AllianceGenome:ZFIN:ZDB-GENE-030131-7118
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    vasp; wu:fb23b04; wu:fk84g05; zgc:110347; si:dkey-113g17.1; si:ch211-202c21.1
    Summary
    Predicted to enable profilin binding activity. Predicted to be involved in actin polymerization or depolymerization; nervous system development; and positive regulation of actin filament polymerization. Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Predicted to be active in focal adhesion and plasma membrane. Is expressed in several structures, including apical ectodermal ridge pectoral fin bud; epidermis; pectoral fin; pharyngeal arch; and solid lens vesicle. Orthologous to human VASP (vasodilator stimulated phosphoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See vaspb in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (40761913..40856271, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (40771721..40866180, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene cyclin P Neighboring gene v-akt murine thymoma viral oncogene homolog 2 Neighboring gene transfer RNA alanine (anticodon UGC) Neighboring gene small nuclear ribonucleoprotein D2 polypeptide Neighboring gene transfer RNA tryptophan (anticodon CCA)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Filopodia and focal adhesions: An integrated system driving branching morphogenesis in neuronal pathfinding and angiogenesis. Fischer RS, et al. Dev Biol, 2019 Jul 1. PMID 30193787, Free PMC Article
    2. Akt2 modulates glucose availability and downstream apoptotic pathways during development. Jensen PJ, et al. J Biol Chem, 2010 Jun 4. PMID 20356836, Free PMC Article
    3. Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Wu Y, et al. Sci Rep, 2017 Jun 22. PMID 28642470, Free PMC Article
    4. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Burguera D, et al. Nat Commun, 2017 Nov 27. PMID 29180615, Free PMC Article
    5. Selecting biologically informative genes in co-expression networks with a centrality score. Azuaje FJ. Biol Direct, 2014 Jun 19. PMID 24947308, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables profilin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neural tube closure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vasodilator stimulated phosphoprotein b; vasodilator-stimulated phosphoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      40761913..40856271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173680.5 → XP_005173737.1  vasodilator-stimulated phosphoprotein isoform X2

      UniProtKB/TrEMBL
      A0A8M2BKY8
      Conserved Domains (2) summary
      cd01207
      Location:5 → 114
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:392 → 422
      VASP_tetra; VASP tetramerization domain

    2. XM_005173679.5 → XP_005173736.1  vasodilator-stimulated phosphoprotein isoform X1

      UniProtKB/TrEMBL
      A0A8M2BKY2, Q1LVK6
      Related
      ENSDARP00000089635.3, ENSDART00000098865.5
      Conserved Domains (2) summary
      cd01207
      Location:5 → 114
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:411 → 441
      VASP_tetra; VASP tetramerization domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395045.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      3592..78830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473340.2 → XP_021329015.1  vasodilator-stimulated phosphoprotein isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q724
      Conserved Domains (1) summary
      cd01207
      Location:5 → 114
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001017790.2: Suppressed sequence

      Description
      NM_001017790.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials