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    mmp2 matrix metallopeptidase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 337179, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mmp2provided by ZNC
    Official Full Name
    matrix metallopeptidase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9123
    See related
    Ensembl:ENSDARG00000017676 AllianceGenome:ZFIN:ZDB-GENE-030131-9123
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa99h12; wu:fk89d01
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in positive regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including hematopoietic stem cell migration; lymph vessel development; and neurogenesis. Located in sarcomere. Is expressed in several structures, including cardiovascular system; digestive system; integument; nervous system; and ovarian follicle. Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mmp2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (35410052..35432817, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (35138575..35161340, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 2 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene uncharacterized LOC101885114 Neighboring gene uncharacterized LOC110439935 Neighboring gene iroquois homeobox 6a Neighboring gene iroquois homeobox 5a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Intracellular Localization in Zebrafish Muscle and Conserved Sequence Features Suggest Roles for Gelatinase A Moonlighting in Sarcomere Maintenance. Fallata AM, et al. Biomedicines, 2019 Nov 29. PMID 31795436, Free PMC Article
    2. Post-translational activation of Mmp2 correlates with patterns of active collagen degradation during the development of the zebrafish tail. Wyatt RA, et al. Dev Biol, 2021 Sep. PMID 34058190
    3. The expression of gelatinase A (MMP-2) is required for normal development of zebrafish embryos. Zhang J, et al. Dev Genes Evol, 2003 Sep. PMID 12898250
    4. The epitope-mediated MMP activation assay: detection and quantification of the activation of Mmp2 in vivo in the zebrafish embryo. Jeffrey EJ, et al. Histochem Cell Biol, 2018 Mar. PMID 29350268
    5. Matrix metalloproteinases in osteoclasts of ontogenetic and regenerating zebrafish scales. de Vrieze E, et al. Bone, 2011 Apr 1. PMID 21185415

    See all (118) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mmp2 facilitates endothelial-to-hematopoietic transition via ECM remodeling.
      Title: Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization.
    2. Dexamethasone and hydrocortisone alter expression and activity of MMP-2 and MMP-9 in the embryonic zebrafish.
      Title: Glucocorticoids alter craniofacial development and increase expression and activity of matrix metalloproteinases in developing zebrafish (Danio rerio).
    3. membrane-type 1 metalloproteinase, zmmp-2, and tissue inhibitor 2 of metalloproteinases mRNA transcripts were expressed in the blastema
      Title: Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic stem cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lymph vessel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retinal ganglion cell axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tissue remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    NOT located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    72 kDa type IV collagenase
    Names
    Gelatinase A
    matrix metalloproteinase 2
    NP_932333.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198067.1 → NP_932333.1  72 kDa type IV collagenase precursor

      See identical proteins and their annotated locations for NP_932333.1

      Status: PROVISIONAL

      Source sequence(s)
      AY324195
      UniProtKB/TrEMBL
      Q7SZM5
      Related
      ENSDARP00000006091.7, ENSDART00000026712.8
      Conserved Domains (4) summary
      smart00059
      Location:342 → 390
      FN2; Fibronectin type 2 domain
      cd00094
      Location:463 → 657
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:118 → 446
      Peptidase_M10; Matrixin
      pfam01471
      Location:70 → 97
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      35410052..35432817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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