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    mis18a MIS18 kinetochore protein A [ Danio rerio (zebrafish) ]

    Gene ID: 553502, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mis18aprovided by ZNC
    Official Full Name
    MIS18 kinetochore protein Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091204-314
    See related
    Ensembl:ENSDARG00000035333 AllianceGenome:ZFIN:ZDB-GENE-091204-314
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-189i22.1
    Summary
    Predicted to be involved in CENP-A containing chromatin assembly and chromosome segregation. Predicted to act upstream of or within cell division. Predicted to be located in chromatin. Predicted to be active in chromosome, centromeric region and nucleus. Orthologous to human MIS18A (MIS18 kinetochore protein A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mis18a in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (33588746..33594111)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (33643958..33650251)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene si:dkey-18a10.3 Neighboring gene cilia and flagella associated protein 298 Neighboring gene eva-1 homolog C (C. elegans) Neighboring gene hormonally up-regulated Neu-associated kinase Neighboring gene beta 3-glucosyltransferase b Neighboring gene uncharacterized LOC101886689

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface. Hunter MV, et al. Nat Commun, 2021 Nov 1. PMID 34725363, Free PMC Article
    2. The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis. Lv Y, et al. J Biol Chem, 2024 Mar. PMID 38382674, Free PMC Article
    3. The splicing factor DHX38 enables retinal development through safeguarding genome integrity. Sun K, et al. iScience, 2023 Nov 17. PMID 37867960, Free PMC Article
    4. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein Mis18-alpha
    Names
    MIS18 kinetochore protein homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      33588746..33594111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479407.2 → XP_021335082.1  protein Mis18-alpha

      UniProtKB/TrEMBL
      A0A8M9PYB8, F1RC19
      Related
      ENSDARP00000051197.5, ENSDART00000051198.6
      Conserved Domains (1) summary
      pfam03226
      Location:39 → 137
      Yippee-Mis18; Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394793.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      4657..10022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002663588.6 → XP_002663634.2  protein Mis18-alpha

      UniProtKB/TrEMBL
      A0A8M9PYB8, F1RC19
      Conserved Domains (1) summary
      pfam03226
      Location:39 → 137
      Yippee-Mis18; Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395291.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      4657..10022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474214.2 → XP_021329889.1  protein Mis18-alpha

      UniProtKB/TrEMBL
      A0A8M9PYB8, F1RC19
      Conserved Domains (1) summary
      pfam03226
      Location:39 → 137
      Yippee-Mis18; Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
    Nucleotide Protein Strain
    Heading Accession and Version

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