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    isg20 interferon stimulated exonuclease gene [ Danio rerio (zebrafish) ]

    Gene ID: 100534720, updated on 9-Dec-2024

    Summary

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    Official Symbol
    isg20provided by ZNC
    Official Full Name
    interferon stimulated exonuclease geneprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100422-17
    See related
    Ensembl:ENSDARG00000079783 AllianceGenome:ZFIN:ZDB-GENE-100422-17
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    INF
    Summary
    Predicted to enable exonuclease activity. Predicted to be involved in RNA processing. Predicted to be active in nucleus. Orthologous to human ISG20 (interferon stimulated exonuclease gene 20). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See isg20 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (19095283..19100472)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (18997270..19002529)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene SAMM50 sorting and assembly machinery component Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 4b Neighboring gene leucine-rich repeats and transmembrane domains 2b Neighboring gene retinaldehyde binding protein 1b Neighboring gene abhydrolase domain containing 2, acylglycerol lipase b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Induction of interferon-stimulated genes and cellular stress pathways by morpholinos in zebrafish. Lai JKH, et al. Dev Biol, 2019 Oct 1. PMID 31201802, Free PMC Article
    2. Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production. Weinreb JT, et al. Dev Cell, 2021 Mar 8. PMID 33651979, Free PMC Article
    3. Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation. Taylor AM, et al. Exp Hematol, 2012 Mar. PMID 22120640, Free PMC Article
    4. Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation. Wu J, et al. Proc Natl Acad Sci U S A, 2023 Jan 3. PMID 36577070, Free PMC Article
    5. Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Li Y, et al. Genes Dev, 2014 Dec 1. PMID 25395663, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    apoptosis-enhancing nuclease
    Names
    interferon-stimulated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      19095283..19100472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470676.2 → XP_021326351.1  apoptosis-enhancing nuclease

      UniProtKB/TrEMBL
      A0A8M9PVI3, E7F5Q4
      Related
      ENSDARP00000128266.1, ENSDART00000154066.2
      Conserved Domains (1) summary
      cd06149
      Location:136 → 292
      ISG20; DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395197.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      15098..20017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003201436.6 → XP_003201484.2  apoptosis-enhancing nuclease

      UniProtKB/TrEMBL
      A0A8M1RN63
      Conserved Domains (1) summary
      cd06149
      Location:136 → 292
      ISG20; DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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