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    pax7a paired box 7a [ Danio rerio (zebrafish) ]

    Gene ID: 30587, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pax7aprovided by ZNC
    Official Full Name
    paired box 7aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-201
    See related
    Ensembl:ENSDARG00000100398 AllianceGenome:ZFIN:ZDB-GENE-990415-201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within developmental pigmentation; regulation of xanthophore differentiation; and wound healing. Located in nucleus. Is expressed in several structures, including central nervous system; muscle; neural crest; neural tube; and post-vent region. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma and congenital myopathy 19. Orthologous to human PAX7 (paired box 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pax7a in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (41243065..41378029)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (40652029..40782812)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene calmodulin-binding transcription activator 1 Neighboring gene mitochondrial ribosomal protein S16 Neighboring gene uncharacterized LOC137490429 Neighboring gene uncharacterized LOC137496734 Neighboring gene parkinson protein 7 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Myocyte Dedifferentiation Drives Extraocular Muscle Regeneration in Adult Zebrafish. Saera-Vila A, et al. Invest Ophthalmol Vis Sci, 2015 Jul. PMID 26230763, Free PMC Article
    2. Oncorhynchus mykiss pax7 sequence variations with comparative analyses against other teleost species. Chapalamadugu KC, et al. Springerplus, 2015. PMID 26090310, Free PMC Article
    3. Generality of vertebrate developmental patterns: evidence for a dermomyotome in fish. Devoto SH, et al. Evol Dev, 2006 Jan-Feb. PMID 16409387, Free PMC Article
    4. Local reorganization of xanthophores fine-tunes and colors the striped pattern of zebrafish. Mahalwar P, et al. Science, 2014 Sep 12. PMID 25214630
    5. Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish. Berberoglu MA, et al. Dev Biol, 2017 Apr 15. PMID 28279710, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cells marked by pax7a only or by both pax7a and pax7b enter the wound rapidly and contribute to muscle wound repair, but each behaves differently.
      Title: Cellular dynamics of regeneration reveals role of two distinct Pax7 stem cell populations in larval zebrafish muscle repair.
    2. Pax7 is required for adult skeletal muscle repair.
      Title: Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish.
    3. Pax7 identifies neural crest, chromatophore lineages and pigment stem cells during development.
      Title: Pax7 identifies neural crest, chromatophore lineages and pigment stem cells during zebrafish development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within developmental pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of xanthophore differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within wound healing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    paired box protein Pax-7a
    Names
    paired box gene 7a
    paired box homeotic gene 7a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131325.2 → NP_571400.1  paired box protein Pax-7a isoform PAX7C

      See identical proteins and their annotated locations for NP_571400.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      CR759952, CU929421
      UniProtKB/TrEMBL
      A0A0R4IPG1, A0A2R8PYQ9, O57418
      Related
      ENSDARP00000138120.1, ENSDART00000172008.3
      Conserved Domains (3) summary
      cd00131
      Location:34 → 166
      PAX; Paired Box domain
      pfam00046
      Location:223 → 276
      Homeobox; Homeobox domain
      pfam12360
      Location:343 → 386
      Pax7; Paired box protein 7

    2. NM_131332.2 → NP_571407.2  paired box protein Pax-7a isoform PAX7D

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      CR759952, CU929421
      UniProtKB/TrEMBL
      A0A0R4IM38, A0A8N1TUG0
      Related
      ENSDARP00000137008.1, ENSDART00000162157.2
      Conserved Domains (3) summary
      cd00131
      Location:34 → 166
      PAX; Paired Box domain
      pfam00046
      Location:223 → 276
      Homeobox; Homeobox domain
      pfam12360
      Location:343 → 386
      Pax7; Paired box protein 7

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      41243065..41378029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009306286.4 → XP_009304561.1  paired box protein Pax-7a isoform X1

      UniProtKB/TrEMBL
      A0A8M3B4A0
      Conserved Domains (3) summary
      cd00131
      Location:34 → 161
      PAX; Paired Box domain
      pfam00046
      Location:218 → 271
      Homeobox; Homeobox domain
      pfam12360
      Location:338 → 381
      Pax7; Paired box protein 7

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394827.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      50661..168175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_131324.2: Suppressed sequence

      Description
      NM_131324.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

    2. NM_131326.1: Suppressed sequence

      Description
      NM_131326.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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