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    sik1 salt-inducible kinase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 553465, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sik1provided by ZNC
    Official Full Name
    salt-inducible kinase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9446
    See related
    Ensembl:ENSDARG00000058606 AllianceGenome:ZFIN:ZDB-GENE-030131-9446
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj78h07; wu:fj78h07; si:ch211-235e18.3
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in bone tissue; gill; heart; kidney; and muscle. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 30. Orthologous to human SIK1 (salt inducible kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sik1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (9112239..9122055)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (9133859..9143725)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496419 Neighboring gene uncharacterized LOC137496449 Neighboring gene cystathionine beta-synthase b Neighboring gene U2 small nuclear RNA auxiliary factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Candidate gene identification of ovulation-inducing genes by RNA sequencing with an in vivo assay in zebrafish. Klangnurak W, et al. PLoS One, 2018. PMID 29715317, Free PMC Article
    2. Transcriptomic Analysis Provides Insights to Reveal the bmp6 Function Related to the Development of Intermuscular Bones in Zebrafish. Xu H, et al. Front Cell Dev Biol, 2022. PMID 35646941, Free PMC Article
    3. MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification. Zimmerman MW, et al. Cancer Discov, 2018 Mar. PMID 29284669, Free PMC Article
    4. Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity. Gans I, et al. Sci Rep, 2020 Jul 10. PMID 32651405, Free PMC Article
    5. Phenotypic analysis of catastrophic childhood epilepsy genes. Griffin A, et al. Commun Biol, 2021 Jun 3. PMID 34083748, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase SIK1
    NP_001119855.1
    XP_005167506.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126383.1 → NP_001119855.1  serine/threonine-protein kinase SIK1

      Status: PROVISIONAL

      Source sequence(s)
      BX537313
      UniProtKB/TrEMBL
      A0A8M1NGM6, B0S6K0
      Related
      ENSDARP00000077468.5, ENSDART00000083033.6
      Conserved Domains (3) summary
      smart00220
      Location:26 → 288
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14408
      Location:309 → 358
      UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)
      cd14071
      Location:25 → 288
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      9112239..9122055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167449.5 → XP_005167506.1  serine/threonine-protein kinase SIK1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2L7B5, A0A8M2BET9
      Related
      ENSDARP00000140668.1, ENSDART00000165932.3
      Conserved Domains (3) summary
      smart00220
      Location:26 → 277
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14408
      Location:298 → 347
      UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)
      cd14071
      Location:25 → 277
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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