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    hapln2 hyaluronan and proteoglycan link protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 558291, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hapln2provided by ZNC
    Official Full Name
    hyaluronan and proteoglycan link protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8089
    See related
    Ensembl:ENSDARG00000003903 AllianceGenome:ZFIN:ZDB-GENE-030131-8089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj51g03; wu:fj51g03; si:dkey-235h8.3
    Summary
    Enables identical protein binding activity. Predicted to be involved in nervous system development; positive regulation of neuroblast proliferation; and skeletal system development. Predicted to act upstream of or within cell adhesion. Predicted to be located in plasma membrane. Predicted to be active in extracellular space; perineuronal net; and synapse. Is expressed in otic placode; otic vesicle; and pharyngeal arch. Orthologous to human HAPLN2 (hyaluronan and proteoglycan link protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hapln2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (29303971..29309912)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (29369348..29375289)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487913 Neighboring gene microRNA 9-1 Neighboring gene Rh family B glycoprotein Neighboring gene brevican Neighboring gene interferon stimulated exonuclease gene 20-like 2 Neighboring gene methyltransferase like 25B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hapln1b, a central organizer of the ECM, modulates kit signaling to control developmental hematopoiesis in zebrafish. Mahony CB, et al. Blood Adv, 2021 Dec 14. PMID 34543380, Free PMC Article
    2. Zebrafish krüppel-like factor 4a represses intestinal cell proliferation and promotes differentiation of intestinal cell lineages. Li IC, et al. PLoS One, 2011. PMID 21687630, Free PMC Article
    3. Large-scale screening for novel low-affinity extracellular protein interactions. Bushell KM, et al. Genome Res, 2008 Apr. PMID 18296487, Free PMC Article
    4. Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Martin S, et al. Mol Cell Proteomics, 2010 Dec. PMID 20802085, Free PMC Article
    5. The impact of gene expression regulation on evolution of extracellular signaling pathways. Charoensawan V, et al. Mol Cell Proteomics, 2010 Dec. PMID 20935258, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in perineuronal net IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hyaluronan and proteoglycan link protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082816.3 → NP_001076285.3  hyaluronan and proteoglycan link protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CR848047
      UniProtKB/TrEMBL
      A4JYQ1
      Related
      ENSDARP00000081583.5, ENSDART00000087149.6

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      29303971..29309912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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