nsun5 NOP2/Sun RNA methyltransferase 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nsun5provided by ZNC
Official Full Name: NOP2/Sun RNA methyltransferase 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2476
See related: Ensembl:ENSDARG00000043209 AllianceGenome:ZFIN:ZDB-GENE-040426-2476
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66176; zgc:77183; wu:fc49f12
Summary: Predicted to enable RNA binding activity and RNA methyltransferase activity. Predicted to act upstream of or within RNA methylation. Orthologous to several human genes including NSUN5 (NOP2/Sun RNA methyltransferase 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (35152959..35163612)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (35209068..35219752)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 28S rRNA (cytosine-C(5))-methyltransferase

Names: NOP2/Sun domain family, member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213285.1 → NP_998450.1 28S rRNA (cytosine-C(5))-methyltransferase

See identical proteins and their annotated locations for NP_998450.1

Status: PROVISIONAL

Source sequence(s)

BC066371

UniProtKB/TrEMBL

Q6NZ28

Related

ENSDARP00000063417.5, ENSDART00000063418.7

Conserved Domains (2) summary

TIGR00446
Location:136 → 416

nop2p; NOL1/NOP2/sun family putative RNA methylase

cl17173
Location:217 → 414

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

35152959..35163612

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009305396.3 → XP_009303671.1 28S rRNA (cytosine-C(5))-methyltransferase isoform X1

UniProtKB/TrEMBL

A0A8M3BD27

Conserved Domains (2) summary

TIGR00446
Location:136 → 416

nop2p; NOL1/NOP2/sun family putative RNA methylase

cl17173
Location:217 → 414

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...