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    gc2 guanylyl cyclase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 140425, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gc2provided by ZNC
    Official Full Name
    guanylyl cyclase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-011128-8
    See related
    Ensembl:ENSDARG00000018329 AllianceGenome:ZFIN:ZDB-GENE-011128-8
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    RETGC-2
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to act upstream of or within several processes, including cyclic nucleotide biosynthetic process; protein phosphorylation; and visual perception. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in eye; retina; and retinal outer nuclear layer. Orthologous to human GUCY2F (guanylate cyclase 2F, retinal). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gc2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (51267799..51294379, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (50992592..51019333, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene collagen, type IV, alpha 5 (Alport syndrome) Neighboring gene insulin receptor substrate 2-B Neighboring gene RAS-like, family 11, member A Neighboring gene ubiquitin specific peptidase 12b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina. Rätscho N, et al. Biochim Biophys Acta, 2009 Jun. PMID 19168097
    2. Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. Brockerhoff SE, et al. J Neurosci, 2003 Jan 15. PMID 12533607, Free PMC Article
    3. Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development. Dong XR, et al. Front Cell Dev Biol, 2022. PMID 35372349, Free PMC Article
    4. Transcripts within rod photoreceptors of the Zebrafish retina. Sun C, et al. BMC Genomics, 2018 Feb 8. PMID 29422031, Free PMC Article
    5. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    retinal guanylyl cyclase 2
    Names
    Gucy2f
    NP_001103165.1
    XP_021333059.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109695.1 → NP_001103165.1  retinal guanylyl cyclase 2

      See identical proteins and their annotated locations for NP_001103165.1

      Status: PROVISIONAL

      Source sequence(s)
      CR381676
      UniProtKB/TrEMBL
      A0A8M1NEV9, E7F111
      Related
      ENSDARP00000089419.1, ENSDART00000098648.3
      Conserved Domains (7) summary
      cd06371
      Location:59 → 440
      PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      PHA02988
      Location:542 → 809
      PHA02988; hypothetical protein; Provisional
      smart00044
      Location:848 → 1040
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14043
      Location:551 → 815
      PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
      pfam00211
      Location:875 → 1062
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:76 → 417
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:824 → 869
      HNOBA; Heme NO binding associated

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      51267799..51294379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477384.2 → XP_021333059.1  retinal guanylyl cyclase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q7H0
      Conserved Domains (4) summary
      cd06371
      Location:59 → 440
      PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      smart00044
      Location:848 → 1040
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14043
      Location:551 → 815
      PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
      pfam07701
      Location:824 → 869
      HNOBA; Heme NO binding associated
    Nucleotide Protein
    Heading Accession and Version

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