sod1 superoxide dismutase 1, soluble [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sod1provided by ZNC
Official Full Name: superoxide dismutase 1, solubleprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-258
See related: Ensembl:ENSDARG00000043848 AllianceGenome:ZFIN:ZDB-GENE-990415-258
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ZSOD; cuzn; Cu/Zn-SOD
Summary: Enables superoxide dismutase activity. Acts upstream of or within several processes, including neuron cellular homeostasis; response to metal ion; and response to methylmercury. Predicted to be located in cytoplasm. Predicted to be active in several cellular components, including cytosol; mitochondrion; and peroxisome. Is expressed in several structures, including blastoderm; cardiovascular system; eye; head mesenchyme; and musculature system. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (25694395..25699429, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (25732682..25737716, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

fenofibrate almost completely abolished GM-induced reactive oxygen species generation, which seemed to be mediated at least in part by the restoration of the expression of PPARalphadependent antioxidant enzymes, including catalase and superoxide dismutase (SOD)-1.
Title: Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes.
The earliest event in the pathophysiology of amyotrohic lateral sclerosis in the mutant sod1 zebrafish model involves neuronal stress in inhibitory interneurons, resulting from mutant Sod1 expression.
Title: Early interneuron dysfunction in ALS: insights from a mutant sod1 zebrafish model.
A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a, sp1 and sod1 in zebrafish.
Title: Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status.
depresses cathepsin L activity stimulated by free radicals and prevents otic complications associated with bone erosion
Title: Cathepsin L activity and its inhibitor in human otitis media.
Copper/zinc superoxide dismutase was cloned from the zebrafish ( Danio rerio). Evidence is presented that SOD protects against paraquat toxicity in fish.
Title: Characterization of fish Cu/Zn-superoxide dismutase and its protection from oxidative stress.
Glia maturation factor-null cells ahow a concurrent decrease in CuZnSOD astrocytes.
Title: Decreased copper-zinc superoxide dismutase activity and increased resistance to oxidative stress in glia maturation factor-null astrocytes.
This isoform, when expressed in PC-12 cells affects t-butylhydroperoxide-induced apoptosis differentially from its isoenzyme.
Title: Differential effects of superoxide dismutase isoform expression on hydroperoxide-induced apoptosis in PC-12 cells.

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General gene information

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Markers

fj44g09.y1 (e-PCR)
- UniSTS:199372

fa96d07 (e-PCR)
- UniSTS:188908

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables superoxide dismutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide dismutase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in removal of superoxide radicals	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to metal ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to methylmercury	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within superoxide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: superoxide dismutase [Cu-Zn]

Names: Cu-Zn superoxide dismutase; sod(Cu/Zn)

NP_571369.1

EC 1.15.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131294.1 → NP_571369.1 superoxide dismutase [Cu-Zn]

See identical proteins and their annotated locations for NP_571369.1

Status: PROVISIONAL

Source sequence(s)

BC055516

UniProtKB/Swiss-Prot

O73872

UniProtKB/TrEMBL

B2GRH9

Related

ENSDARP00000064375.4, ENSDART00000064376.5

Conserved Domains (1) summary

cd00305
Location:4 → 147

Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...