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    hsd17b12b hydroxysteroid (17-beta) dehydrogenase 12b [ Danio rerio (zebrafish) ]

    Gene ID: 322626, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hsd17b12bprovided by ZNC
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 12bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1346
    See related
    Ensembl:ENSDARG00000035872 AllianceGenome:ZFIN:ZDB-GENE-030131-1346
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    KAR; fb68b12; zgc:73289; wu:fb68b12
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in estrogen biosynthetic process and fatty acid biosynthetic process. Predicted to act upstream of or within steroid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hsd17b12b in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (50228015..50272871, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (49955239..50000095, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene APAF1 interacting protein Neighboring gene leucine rich repeat containing 4C, genome duplicate b Neighboring gene uncharacterized LOC110439945 Neighboring gene microRNA 129-2 Neighboring gene tetratricopeptide repeat domain 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of 17 beta-hydroxysteroid dehydrogenases in the zebrafish, Danio rerio. Mindnich R, et al. Mol Cell Endocrinol, 2004 Feb 27. PMID 15026171
    2. Discovery of a novel enzyme mediating glucocorticoid catabolism in fish: 20beta-hydroxysteroid dehydrogenase type 2. Tokarz J, et al. Mol Cell Endocrinol, 2012 Feb 26. PMID 22061621
    3. Beta-Hydroxysteroid Dehydrogenase Genes in Orange-Spotted Grouper (Epinephelus coioides): Genome-Wide Identification and Expression Analysis During Sex Reversal. Xiao L, et al. Front Genet, 2020. PMID 32194632, Free PMC Article
    4. Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Takashima S, et al. Mol Genet Metab, 2021 Jul. PMID 34016526
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very-long-chain 3-oxoacyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in estrogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    very-long-chain 3-oxoacyl-CoA reductase-B
    Names
    17-beta hydroxysteroid dehydrogenase type 12B, 3-ketoacyl-CoA reductase type B
    17-beta-HSD 12-B
    17-beta-hydroxysteroid dehydrogenase 12-B
    3-ketoacyl-CoA reductase
    estradiol 17-beta-dehydrogenase 12-B
    zf 3.3
    zf3.3
    zfHSD17B12B
    NP_955907.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199613.1 → NP_955907.1  very-long-chain 3-oxoacyl-CoA reductase-B

      See identical proteins and their annotated locations for NP_955907.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059617
      UniProtKB/Swiss-Prot
      Q6PBR0, Q6QA33
      UniProtKB/TrEMBL
      A7MCK2
      Related
      ENSDARP00000089612.3, ENSDART00000098842.5
      Conserved Domains (2) summary
      PLN02780
      Location:8 → 307
      PLN02780; ketoreductase/ oxidoreductase
      cd05356
      Location:48 → 285
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      50228015..50272871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6QA33.2 GenPept UniProtKB/Swiss-Prot:Q6QA33

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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