clic4 chloride intracellular channel 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: clic4provided by ZNC
Official Full Name: chloride intracellular channel 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-030326-3
See related: Ensembl:ENSDARG00000022995 AllianceGenome:ZFIN:ZDB-GENE-030326-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb142; wu:fb33c05; wu:fc30h10
Summary: Predicted to enable chloride channel activity. Predicted to be involved in chloride transport. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in several cellular components, including anchoring junction; cytoplasmic vesicle; and mitochondrion. Predicted to be part of chloride channel complex. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including axis; central nervous system; immature eye; mesoderm; and pericardial region. Orthologous to human CLIC4 (chloride intracellular channel 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (25444424..25480375)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (25426033..25461984)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI416041 (e-PCR)
- UniSTS:206630

fc30h10.x1 (e-PCR)
- UniSTS:187949

fc30h10.x1 (e-PCR)
- UniSTS:187950

G46334 (e-PCR)
- UniSTS:107136

fb53a07.y1 (e-PCR)
- UniSTS:190671

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chloride intracellular channel protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201486.1 → NP_958894.1 chloride intracellular channel protein 4

See identical proteins and their annotated locations for NP_958894.1

Status: PROVISIONAL

Source sequence(s)

BC051622

UniProtKB/TrEMBL

F6NVW6, Q6P0I1, Q7ZTT4

Related

ENSDARP00000035859.4, ENSDART00000030691.6

Conserved Domains (3) summary

TIGR00862
Location:16 → 250

O-ClC; intracellular chloride channel protein

cd10296
Location:110 → 250

GST_C_CLIC4; C-terminal, alpha helical domain of Chloride Intracellular Channel 4

cd03061
Location:13 → 103

GST_N_CLIC; GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated ...