myl12.1 myosin, light chain 12, genome duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myl12.1provided by ZNC
Official Full Name: myosin, light chain 12, genome duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4918
See related: Ensembl:ENSDARG00000099766 AllianceGenome:ZFIN:ZDB-GENE-030131-4918
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mlc-4; myl9l; bing3y; mlc12.1; zeh0157; zgc:65791; hm:zeh0157; wu:fa93e09; wu:fe06h06
Summary: Predicted to enable calcium ion binding activity. Predicted to be active in cytoplasm. Orthologous to human MYL12A (myosin light chain 12A) and MYL12B (myosin light chain 12B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (71764701..71772711)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (71572909..71580919)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fa93e09.x1 (e-PCR)
- UniSTS:202580

AW174891 (e-PCR)
- UniSTS:205800

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin, light chain 12, genome duplicate 1

Names: bing3 like; myosin, light polypeptide 9, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214699.2 → NP_999864.1 myosin, light chain 12, genome duplicate 1

See identical proteins and their annotated locations for NP_999864.1

Status: VALIDATED

Source sequence(s)

CU607104, EH434629, EH557418

UniProtKB/TrEMBL

A0A8M1PJZ2, A0A8M9PKQ2, F1QYK9, Q6PHJ8

Related

ENSDARP00000137464.1, ENSDART00000171996.2

Conserved Domains (3) summary

COG5126
Location:19 → 169

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:33 → 77

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl08302
Location:103 → 164

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...