dus2 dihydrouridine synthase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dus2provided by ZNC
Official Full Name: dihydrouridine synthase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-100922-233
See related: Ensembl:ENSDARG00000077607 AllianceGenome:ZFIN:ZDB-GENE-100922-233
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dus2l; si:ch73-46g7.4
Summary: Predicted to enable tRNA dihydrouridine synthase activity. Predicted to be involved in tRNA dihydrouridine synthesis. Predicted to act upstream of or within tRNA processing. Predicted to be active in cytoplasm. Orthologous to human DUS2 (dihydrouridine synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (36249675..36263132, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (35699956..35713457, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fc19d03.y1 (e-PCR)
- UniSTS:192919

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables tRNA dihydrouridine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA dihydrouridine synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tRNA dihydrouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tRNA-dihydrouridine synthase 2-like; tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

Names: dihydrouridine synthase 2-like, SMM1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007136.7 Reference GRCz11 Primary Assembly

Range

36249675..36263132 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001342658.7 → XP_001342694.3 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

See identical proteins and their annotated locations for XP_001342694.3

UniProtKB/TrEMBL

A0A8M1Q231, E7F220

Related

ENSDARP00000115556.1, ENSDART00000139002.3

Conserved Domains (3) summary

COG0042
Location:15 → 259

DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]

cd00048
Location:372 → 437

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

cd02801
Location:18 → 263

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
XM_005163191.5 → XP_005163248.1 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

See identical proteins and their annotated locations for XP_005163248.1

UniProtKB/TrEMBL

A0A8M1Q231, E7F220

Conserved Domains (3) summary

COG0042
Location:15 → 259

DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]

cd00048
Location:372 → 437

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

cd02801
Location:18 → 263

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...