wnt2ba wingless-type MMTV integration site family, member 2Ba [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wnt2baprovided by ZNC
Official Full Name: wingless-type MMTV integration site family, member 2Baprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030717-2
See related: Ensembl:ENSDARG00000005050 AllianceGenome:ZFIN:ZDB-GENE-030717-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wnt2b
Summary: Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within embryonic pectoral fin morphogenesis; podocyte development; and sensory epithelium regeneration. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in brain; immature eye; mesoderm; and pronephros. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human WNT2B (Wnt family member 2B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (48253451..48271687)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (48254631..48272928)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data reveal an unexpected positive role for Wnt signalling in liver specification, and indicate a possible common theme for the localized formation of endodermal organs along the gut tube
Title: Mesodermal Wnt2b signalling positively regulates liver specification.
Retinoic acid signaling from the somitic mesoderm leads to activation of wnt2b expression in the intermediate mesoderm.
Title: Prdm1 acts downstream of a sequential RA, Wnt and Fgf signaling cascade during zebrafish forelimb induction.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic pectoral fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within podocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory epithelium regeneration	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: wingless-type MMTV integration site family, member 2Ba

Names: wingless-type MMTV integration site family, member 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.