dnaaf6 dynein axonemal assembly factor 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dnaaf6provided by ZNC
Official Full Name: dynein axonemal assembly factor 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-040722-2
See related: Ensembl:ENSDARG00000038612 AllianceGenome:ZFIN:ZDB-GENE-040722-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pih1d3; MGC35261l
Summary: Predicted to enable dynein intermediate chain binding activity. Acts upstream of or within axonemal dynein complex assembly. Predicted to be active in cytoplasm. Is expressed in Kupffer's vesicle; floor plate; otic placode; otic vesicle; and pronephric duct. Used to study primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 36. Orthologous to human DNAAF6 (dynein axonemal assembly factor 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (44400773..44406109, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (44547775..44553142, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axonemal dynein complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axonemal dynein complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axonemal dynein complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dynein axonemal assembly factor 6

Names: PIH1 domain containing 3; twister

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002309.1 → NP_001002309.1 dynein axonemal assembly factor 6

See identical proteins and their annotated locations for NP_001002309.1

Status: PROVISIONAL

Source sequence(s)

AY618927

UniProtKB/TrEMBL

A0A8M1N078, Q6IVV7

Related

ENSDARP00000056374.4, ENSDART00000056375.5

Conserved Domains (1) summary

cl00175
Location:45 → 183

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.