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    snrpa small nuclear ribonucleoprotein polypeptide A [ Danio rerio (zebrafish) ]

    Gene ID: 324121, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snrpaprovided by ZNC
    Official Full Name
    small nuclear ribonucleoprotein polypeptide Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2841
    See related
    Ensembl:ENSDARG00000018890 AllianceGenome:ZFIN:ZDB-GENE-030131-2841
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc19d01; zgc:77810; wu:fc19d01
    Summary
    Predicted to enable U1 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be part of U1 snRNP. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA (small nuclear ribonucleoprotein polypeptide A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See snrpa in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (35403042..35407695, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (35428196..35432849, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene transforming growth factor beta regulator 1 Neighboring gene protein jagged-1b Neighboring gene uncharacterized LOC137488314 Neighboring gene actin maturation protease Neighboring gene inositol-trisphosphate 3-kinase Cb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of the testis and ovary transcriptomes in zebrafish by combining experimental and computational tools. Li Y, et al. Comp Funct Genomics, 2004. PMID 18629171, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U1 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U1 small nuclear ribonucleoprotein A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199671.1 → NP_955965.1  U1 small nuclear ribonucleoprotein A

      See identical proteins and their annotated locations for NP_955965.1

      Status: PROVISIONAL

      Source sequence(s)
      BC064308
      UniProtKB/TrEMBL
      A0A8M1P9Z9, Q6P2T1
      Related
      ENSDARP00000153873.1, ENSDART00000191845.1
      Conserved Domains (3) summary
      COG0724
      Location:9 → 98
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12477
      Location:7 → 95
      RRM1_U1A; RNA recognition motif 1 found in vertebrate U1 small nuclear ribonucleoprotein A (U1A)
      cd12480
      Location:202 → 281
      RRM2_U1A; RNA recognition motif 2 found in vertebrate U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A or U1A)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      35403042..35407695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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