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    ercc6l excision repair cross-complementation group 6-like [ Danio rerio (zebrafish) ]

    Gene ID: 100005291, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ercc6lprovided by ZNC
    Official Full Name
    excision repair cross-complementation group 6-likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060531-56
    See related
    Ensembl:ENSDARG00000002479 AllianceGenome:ZFIN:ZDB-GENE-060531-56
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-278b8.3
    Summary
    Predicted to enable DNA translocase activity. Predicted to be involved in DNA repair. Predicted to act upstream of or within cell division and intein-mediated protein splicing. Predicted to be located in kinetochore. Orthologous to human ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ercc6l in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (23913660..23926253)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (23406795..23422723)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 6 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1a Neighboring gene uncharacterized LOC137495586 Neighboring gene uncharacterized LOC137495587

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury. Zuppo DA, et al. Development, 2023 Mar 15. PMID 36846912, Free PMC Article
    2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA translocase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intein-mediated protein splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA excision repair protein ERCC-6-like
    Names
    ATP-dependent helicase ERCC6-like
    excision repair cross-complementing rodent repair deficiency, complementation group 6-like
    NP_001093563.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100093.2 → NP_001093563.1  DNA excision repair protein ERCC-6-like

      See identical proteins and their annotated locations for NP_001093563.1

      Status: PROVISIONAL

      Source sequence(s)
      BX510925, CR391924
      UniProtKB/Swiss-Prot
      A2BGR3, A7E225
      UniProtKB/TrEMBL
      A0A8M3AS17
      Related
      ENSDARP00000012447.6, ENSDART00000015401.7
      Conserved Domains (3) summary
      cd00046
      Location:125 → 268
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:108 → 431
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:474 → 589
      Helicase_C; Helicase conserved C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      23913660..23926253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2BGR3.1 GenPept UniProtKB/Swiss-Prot:A2BGR3

    Gene LinkOut

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