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    ndufa9a NADH:ubiquinone oxidoreductase subunit A9a [ Danio rerio (zebrafish) ]

    Gene ID: 541331, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ndufa9aprovided by ZNC
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit A9aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050320-20
    See related
    Ensembl:ENSDARG00000070723 AllianceGenome:ZFIN:ZDB-GENE-050320-20
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ndufa9; wu:fc41f12; zgc:112513
    Summary
    Acts upstream of or within response to hypoxia. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; immature eye; midbrain; musculature system; and retina. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 26. Orthologous to human NDUFA9 (NADH:ubiquinone oxidoreductase subunit A9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ndufa9a in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (16772531..16782135, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (16676131..16685735, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene RIB43A domain with coiled-coils 2 Neighboring gene probable polypeptide N-acetylgalactosaminyltransferase 8 Neighboring gene dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 Neighboring gene zgc:154077

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Gene expression profiling of the long-term adaptive response to hypoxia in the gills of adult zebrafish. van der Meer DL, et al. Am J Physiol Regul Integr Comp Physiol, 2005 Nov. PMID 15994372
    2. A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity. Zou YY, et al. Nutrients, 2022 May 9. PMID 35565942, Free PMC Article
    3. Regular exercise attenuates alcoholic myopathy in zebrafish by modulating mitochondrial homeostasis. Wen W, et al. PLoS One, 2023. PMID 38032938, Free PMC Article
    4. Depletion of stearoyl-CoA desaturase (scd) leads to fatty liver disease and defective mating behavior in zebrafish. Xu SS, et al. Zool Res, 2023 Jan 18. PMID 36317480, Free PMC Article
    5. FusX: A Rapid One-Step Transcription Activator-Like Effector Assembly System for Genome Science. Ma AC, et al. Hum Gene Ther, 2016 Jun. PMID 26854857, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to hypoxia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9a
    NP_001013477.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013459.2 → NP_001013477.2  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      BC153422, DV588298
      UniProtKB/TrEMBL
      A0A8N7UY68, A8E515, F6NP87
      Related
      ENSDARP00000007735.8, ENSDART00000019413.11
      Conserved Domains (2) summary
      cd05271
      Location:58 → 329
      NDUFA9_like_SDR_a; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs
      pfam01370
      Location:58 → 266
      Epimerase; NAD dependent epimerase/dehydratase family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      16772531..16782135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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