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    wasf2 WASP family member 2 [ Danio rerio (zebrafish) ]

    Gene ID: 394056, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wasf2provided by ZNC
    Official Full Name
    WASP family member 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-865
    See related
    Ensembl:ENSDARG00000024209 AllianceGenome:ZFIN:ZDB-GENE-040426-865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56010
    Summary
    Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Acts upstream of or within heart development. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of SCAR complex. Predicted to be active in lamellipodium. Orthologous to human WASF2 (WASP family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See wasf2 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (43523675..43543128)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (43928061..43947531)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene AT hook, DNA binding motif, containing 1 Neighboring gene probable methyltransferase-like protein 24 Neighboring gene G protein-coupled receptor 3 Neighboring gene CD164 sialomucin-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. Edwards JJ, et al. JACC Basic Transl Sci, 2020 Apr. PMID 32368696, Free PMC Article
    2. The cellular architecture and molecular determinants of the zebrafish fusogenic synapse. Luo Z, et al. Dev Cell, 2022 Jul 11. PMID 35709765, Free PMC Article
    3. Incomplete splicing, cell division defects, and hematopoietic blockage in dhx8 mutant zebrafish. English MA, et al. Dev Dyn, 2012 May. PMID 22411201, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56010

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    actin-binding protein WASF2
    Names
    WAS protein family, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328190.1 → NP_001315119.1  actin-binding protein WASF2

      Status: VALIDATED

      Source sequence(s)
      BX649384
      UniProtKB/TrEMBL
      A0A8M1P4I3, Q1LVV3
      Related
      ENSDARP00000104195.2, ENSDART00000113031.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      43523675..43543128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017352208.3 → XP_017207697.1  actin-binding protein WASF2 isoform X1

      UniProtKB/TrEMBL
      A0A8M1P4I3, Q1LVV3

    2. XM_068215052.1 → XP_068071153.1  actin-binding protein WASF2 isoform X1

      UniProtKB/TrEMBL
      A0A8M1P4I3, Q1LVV3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_201081.1: Suppressed sequence

      Description
      NM_201081.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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