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    hpcal1 hippocalcin-like 1 [ Danio rerio (zebrafish) ]

    Gene ID: 394139, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hpcal1provided by ZNC
    Official Full Name
    hippocalcin-like 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1242
    See related
    Ensembl:ENSDARG00000022763 AllianceGenome:ZFIN:ZDB-GENE-040426-1242
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63695
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of signal transduction. Orthologous to human HPCAL1 (hippocalcin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hpcal1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (31231159..31252832, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (31330042..31349693, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene otoferlin a Neighboring gene protein disulfide isomerase family A, member 6 Neighboring gene apolipoprotein Bb, tandem duplicate 1 Neighboring gene solute carrier family 22 member 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish. Xiong Z, et al. Elife, 2021 Feb 16. PMID 33591275, Free PMC Article
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC63695

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    hippocalcin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201164.1 → NP_957458.1  hippocalcin-like protein 1

      See identical proteins and their annotated locations for NP_957458.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055210
      UniProtKB/TrEMBL
      A0A8M2B7I6, Q7SXX4
      Related
      ENSDARP00000038816.3, ENSDART00000028471.5
      Conserved Domains (3) summary
      COG5126
      Location:13 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:100 → 174
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl08302
      Location:36 → 89
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      31231159..31252832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160651.5 → XP_005160708.1  hippocalcin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005160708.1

      UniProtKB/TrEMBL
      A0A8M2B7I6, Q7SXX4
      Related
      ENSDARP00000114371.1, ENSDART00000137236.3
      Conserved Domains (3) summary
      COG5126
      Location:13 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:100 → 174
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl08302
      Location:36 → 89
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. XM_068215398.1 → XP_068071499.1  hippocalcin-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B7I6, Q7SXX4
    Nucleotide Protein Strain
    Heading Accession and Version

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