dzip1l DAZ interacting zinc finger protein 1-like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dzip1lprovided by ZNC
Official Full Name: DAZ interacting zinc finger protein 1-likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-051113-196
See related: Ensembl:ENSDARG00000074265 AllianceGenome:ZFIN:ZDB-GENE-051113-196
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:123017
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within cilium assembly. Predicted to be located in centriole. Predicted to be active in ciliary basal body and cytoplasm. Is expressed in olfactory placode and pronephric duct. Human ortholog(s) of this gene implicated in polycystic kidney disease 5. Orthologous to human DZIP1L (DAZ interacting zinc finger protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (26309878..26353179)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (26323903..26362618)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inactivation of dzip1l with morpholino antisense oligonucleotides causes phenotypes consistent with ciliary dysfunction. There are defects in glomerular and pronephric tubules in transgenic embryos blocked with these morpholino oligos.CRISPR-Cas9 deletion of exons 2 and 13 caused highly penetrant defects in otolith deposition but no additional abnormalities.
Title: Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein localization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cilium assembly protein DZIP1L

Names: DAZ interacting protein 1-like; DAZ-interacting protein 1-like protein; zinc finger protein DZIP1L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.