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    ppp4r4 protein phosphatase 4, regulatory subunit 4 [ Danio rerio (zebrafish) ]

    Gene ID: 567930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppp4r4provided by ZNC
    Official Full Name
    protein phosphatase 4, regulatory subunit 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041001-164
    See related
    Ensembl:ENSDARG00000010407 AllianceGenome:ZFIN:ZDB-GENE-041001-164
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-85n7.3
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein serine/threonine phosphatase complex. Predicted to be active in cytosol. Orthologous to human PPP4R4 (protein phosphatase 4 regulatory subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ppp4r4 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (27297152..27372450)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (27431319..27473355)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:dkey-85n7.8 Neighboring gene proline rich membrane anchor 1 Neighboring gene ankyrin repeat and SOCS box containing 2a, tandem duplicate 1 Neighboring gene ankyrin repeat and SOCS box containing 2a, tandem duplicate 2 Neighboring gene serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10a Neighboring gene peripherin 2-like b Neighboring gene transmembrane protein 179a, genome duplicate A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein serine/threonine phosphatase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 4 regulatory subunit 4
    Names
    HEAT-like repeat-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      27297152..27372450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215644.1 → XP_068071745.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X4

    2. XM_068215645.1 → XP_068071746.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X5

    3. XM_005160611.5 → XP_005160668.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_005160668.1

      UniProtKB/TrEMBL
      A0A8M2B7H1, F1QXK8
      Related
      ENSDARP00000018496.6, ENSDART00000013861.8
      Conserved Domains (1) summary
      sd00044
      Location:130 → 158
      HEAT; HEAT repeat [structural motif]

    4. XM_021468636.2 → XP_021324311.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PPX9
      Conserved Domains (1) summary
      sd00044
      Location:130 → 158
      HEAT; HEAT repeat [structural motif]

    5. XM_691244.9 → XP_696336.5  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2

      UniProtKB/TrEMBL
      A0A8N7TBQ5
      Conserved Domains (1) summary
      sd00044
      Location:130 → 158
      HEAT; HEAT repeat [structural motif]

    6. XM_068215646.1 → XP_068071747.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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