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    usp21 ubiquitin specific peptidase 21 [ Danio rerio (zebrafish) ]

    Gene ID: 563546, updated on 9-Dec-2024

    Summary

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    Official Symbol
    usp21provided by ZNC
    Official Full Name
    ubiquitin specific peptidase 21provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100210-3
    See related
    Ensembl:ENSDARG00000094280 AllianceGenome:ZFIN:ZDB-GENE-100210-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within central nervous system morphogenesis and cranial skeletal system development. Orthologous to human USP21 (ubiquitin specific peptidase 21). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See usp21 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (20687340..20701863)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (20760997..20775518)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-like modifier activating enzyme 1 Neighboring gene Rho guanine nucleotide exchange factor (GEF) 3, like Neighboring gene coiled-coil domain containing 30 Neighboring gene zinc finger protein 362b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Importance of deubiquitinases in zebrafish craniofacial development. Tse WKF. Biochem Biophys Res Commun, 2017 Jun 10. PMID 28450118
    2. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within central nervous system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cranial skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      20687340..20701863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162129.5 → XP_005162186.1  ubiquitin carboxyl-terminal hydrolase 21 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B8Z0
      Conserved Domains (2) summary
      cd02674
      Location:63 → 396
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:62 → 395
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. XM_686911.9 → XP_692003.2  ubiquitin carboxyl-terminal hydrolase 21 isoform X2

      UniProtKB/TrEMBL
      A0A8N7TF44, E9QFQ5
      Related
      ENSDARP00000122828.2, ENSDART00000143503.3
      Conserved Domains (2) summary
      cd02674
      Location:63 → 395
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:62 → 394
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version

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