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    poc5 POC5 centriolar protein homolog (Chlamydomonas) [ Danio rerio (zebrafish) ]

    Gene ID: 562608, updated on 4-Jan-2025

    Summary

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    Official Symbol
    poc5provided by ZNC
    Official Full Name
    POC5 centriolar protein homolog (Chlamydomonas)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060526-135
    See related
    Ensembl:ENSDARG00000059982 AllianceGenome:ZFIN:ZDB-GENE-060526-135
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-254o18.1
    Summary
    Acts upstream of or within eye photoreceptor cell development and visual behavior. Located in photoreceptor connecting cilium. Is expressed in brain; head; oocyte; photoreceptor cell; and tail bud. Used to study retinitis pigmentosa. Orthologous to human POC5 (POC5 centriolar protein). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See poc5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (45938314..45958846, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (45338163..45358699, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene interferon gamma receptor 2 Neighboring gene polymerase (DNA directed) kappa Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene uncharacterized LOC137495626 Neighboring gene synaptic vesicle glycoprotein 2Ca

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Whole-exome sequencing reveals POC5 as a novel gene associated with autosomal recessive retinitis pigmentosa. Weisz Hubshman M, et al. Hum Mol Genet, 2018 Feb 15. PMID 29272404
    2. Functional variants of POC5 identified in patients with idiopathic scoliosis. Patten SA, et al. J Clin Invest, 2015 Mar 2. PMID 25642776, Free PMC Article
    3. Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. Casey MA, et al. G3 (Bethesda), 2022 Mar 4. PMID 35079792, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in eye photoreceptor cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within eye photoreceptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within visual behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in photoreceptor connecting cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in photoreceptor connecting cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centrosomal protein POC5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      45938314..45958846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165248.5 → XP_005165305.1  centrosomal protein POC5 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BCI3
      Conserved Domains (1) summary
      TIGR02168
      Location:183 → 347
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_685988.9 → XP_691080.3  centrosomal protein POC5 isoform X1

      UniProtKB/TrEMBL
      A0A8N7T784, B0S5R1
      Related
      ENSDARP00000121737.1, ENSDART00000135072.3
      Conserved Domains (1) summary
      TIGR02168
      Location:184 → 348
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein
    Heading Accession and Version

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