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    septin9b septin 9b [ Danio rerio (zebrafish) ]

    Gene ID: 541494, updated on 9-Dec-2024

    Summary

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    Official Symbol
    septin9bprovided by ZNC
    Official Full Name
    septin 9bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050327-17
    See related
    Ensembl:ENSDARG00000103900 AllianceGenome:ZFIN:ZDB-GENE-050327-17
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sept9b; zgc:113041
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis and protein localization. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Human ortholog(s) of this gene implicated in brachial plexus neuritis and colorectal cancer. Orthologous to human SEPTIN9 (septin 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See septin9b in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (18937386..19035760, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (22466065..22564439, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene trinucleotide repeat containing adaptor 6C2 Neighboring gene uncharacterized LOC137495951 Neighboring gene si:rp71-81e14.2 Neighboring gene si:ch211-188c18.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing of sept9a and sept9b in zebrafish produces multiple mRNA transcripts expressed throughout development. Landsverk ML, et al. PLoS One, 2010 May 19. PMID 20502708, Free PMC Article
    2. Phylogenetic and evolutionary analysis of the septin protein family in metazoan. Cao L, et al. FEBS Lett, 2007 Nov 27. PMID 17967425
    3. Zebrafish null mutants of Sept6 and Sept15 are viable but more susceptible to Shigella infection. Torraca V, et al. Cytoskeleton (Hoboken), 2023 Jul-Aug. PMID 36855298, Free PMC Article
    4. Analysis of protein expression in zebrafish during gonad differentiation by targeted proteomics. Groh KJ, et al. Gen Comp Endocrinol, 2013 Nov 1. PMID 23968773
    5. Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. Gomez GA, et al. PLoS One, 2009. PMID 19308258, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zebrafish possess two genes, sept9a and sept9b that, like humans, express multiple transcripts.
      Title: Alternative splicing of sept9a and sept9b in zebrafish produces multiple mRNA transcripts expressed throughout development.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    septin 9b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014307.3 → NP_001014329.1  septin 9b isoform c

      See identical proteins and their annotated locations for NP_001014329.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AL954176
      UniProtKB/TrEMBL
      A0A2R8QDE4, A0A2R8QM64, Q58EK7
      Related
      ENSDARP00000135971.1, ENSDART00000170039.2
      Conserved Domains (2) summary
      cd01850
      Location:38 → 312
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:20 → 324
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    2. NM_001327974.1 → NP_001314903.1  septin 9b isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AL954176, CR925723
      UniProtKB/TrEMBL
      A0A2R8Q8Y9, A0A8M1P8L4
      Related
      ENSDARP00000149599.1, ENSDART00000187714.1
      Conserved Domains (2) summary
      cd01850
      Location:262 → 536
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:244 → 548
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    3. NM_001327975.1 → NP_001314904.1  septin 9b isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL954176, CR925723
      UniProtKB/TrEMBL
      A0A2R8QHK6, A0A8M1P436
      Related
      ENSDARP00000153491.1, ENSDART00000184729.1
      Conserved Domains (2) summary
      cd01850
      Location:261 → 535
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:243 → 547
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    4. NM_001327977.1 → NP_001314906.1  septin 9b isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AL954176
      UniProtKB/TrEMBL
      A0A2R8QDE4, A0A2R8QM64, Q58EK7
      Related
      ENSDARP00000154121.1, ENSDART00000185278.1
      Conserved Domains (2) summary
      cd01850
      Location:38 → 312
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:20 → 324
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      18937386..19035760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394637.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      442729..543819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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