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    sh2d3cb SH2 domain containing 3Cb [ Danio rerio (zebrafish) ]

    Gene ID: 394051, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sh2d3cbprovided by ZNC
    Official Full Name
    SH2 domain containing 3Cbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1052
    See related
    Ensembl:ENSDARG00000104555 AllianceGenome:ZFIN:ZDB-GENE-040426-1052
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sh2d3c; zgc:56490
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and phosphotyrosine residue binding activity. Predicted to act upstream of or within small GTPase-mediated signal transduction. Is expressed in nervous system; neural tube; and trigeminal placode. Orthologous to human SH2D3C (SH2 domain containing 3C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sh2d3cb in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (65124168..65158203, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (64434991..64469206, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene microRNA 219-2 Neighboring gene torsin family 2, member A Neighboring gene cilia and flagella associated protein 157 Neighboring gene collagen, type XXVII, alpha 1b Neighboring gene microRNA 455 Neighboring gene uncharacterized LOC110439792

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of genes expressed by zebrafish oligodendrocytes using a differential microarray screen. Takada N, et al. Dev Dyn, 2010 Jul. PMID 20549738
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC56490

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SH2 domain containing 3Cb
    Names
    SH2 domain containing 3C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201076.1 → NP_957370.1  SH2 domain containing 3Cb

      See identical proteins and their annotated locations for NP_957370.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049321
      UniProtKB/TrEMBL
      Q7ZUD0
      Related
      ENSDARP00000140658.1, ENSDART00000171656.2
      Conserved Domains (2) summary
      cd10337
      Location:43 → 178
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:365 → 533
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      65124168..65158203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476041.2 → XP_021331716.1  SH2 domain containing 3Cb isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCW0
      Conserved Domains (2) summary
      cd10337
      Location:37 → 172
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:359 → 527
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    2. XM_005165604.5 → XP_005165661.1  SH2 domain containing 3Cb isoform X1

      See identical proteins and their annotated locations for XP_005165661.1

      UniProtKB/TrEMBL
      A0A8M2BCW0
      Conserved Domains (2) summary
      cd10337
      Location:37 → 172
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:359 → 527
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394621.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      41807..71488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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