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    neff1 neuronal intermediate filament family member 1 [ Danio rerio (zebrafish) ]

    Gene ID: 321113, updated on 27-Dec-2024

    Summary

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    Official Symbol
    neff1provided by ZNC
    Official Full Name
    neuronal intermediate filament family member 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9669
    See related
    Ensembl:ENSDARG00000012281 AllianceGenome:ZFIN:ZDB-GENE-030131-9669
    Gene type
    protein coding
    RefSeq status
    PREDICTED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Ina; cb126; sb:cb126; zgc:65851
    Summary
    Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in intermediate filament organization. Predicted to be active in cytoplasm and intermediate filament. Is expressed in nervous system and neural tube. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See neff1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (13671614..13684777, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (13171397..13184560, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene purine-rich element binding protein Ba Neighboring gene H2A.Z variant histone 2a Neighboring gene MAX dimerization protein 1 Neighboring gene uncharacterized LOC137495562 Neighboring gene small nuclear ribonucleoprotein 27 (U4/U6.U5)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Developmental pattern of the neuronal intermediate filament inaa in the zebrafish retina. Liao ML, et al. J Comp Neurol, 2016 Dec 15. PMID 27159642
    2. Integrated analyses of zebrafish miRNA and mRNA expression profiles identify miR-29b and miR-223 as potential regulators of optic nerve regeneration. Fuller-Carter PI, et al. BMC Genomics, 2015 Aug 12. PMID 26265132, Free PMC Article
    3. Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. England SJ, et al. Neural Dev, 2023 Nov 28. PMID 38017520, Free PMC Article
    4. Proteomic profile of zebrafish brain based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis. Singh SK, et al. Zebrafish, 2010 Jun. PMID 20528263
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intermediate filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC321113
    Names
    internexin neuronal intermediate filament protein, alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199534.1 → NP_955828.1  uncharacterized protein LOC321113

      See identical proteins and their annotated locations for NP_955828.1

      Status: PREDICTED

      Source sequence(s)
      BC056314
      UniProtKB/TrEMBL
      F6NKW3, Q6NZX1, Q7SZP4
      Related
      ENSDARP00000012500.6, ENSDART00000018351.7
      Conserved Domains (3) summary
      pfam00038
      Location:95 → 405
      Filament; Intermediate filament protein
      pfam04732
      Location:8 → 94
      Filament_head; Intermediate filament head (DNA binding) region
      pfam07798
      Location:311 → 400
      DUF1640; Protein of unknown function (DUF1640)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      13671614..13684777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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