U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lrp1ab low density lipoprotein receptor-related protein 1Ab [ Danio rerio (zebrafish) ]

    Gene ID: 565797, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    lrp1abprovided by ZNC
    Official Full Name
    low density lipoprotein receptor-related protein 1Abprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7126
    See related
    Ensembl:ENSDARG00000029146 AllianceGenome:ZFIN:ZDB-GENE-030131-7126
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lrp1; lrp1b; fk86b07; wu:fk86b07; si:ch73-60e21.3
    Summary
    Predicted to enable apolipoprotein binding activity and cargo receptor activity. Acts upstream of or within regulation of vasculature development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See lrp1ab in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    90
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (25451559..25687368, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (25525014..25760861, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene extended synaptotagmin-like protein 1a Neighboring gene uncharacterized LOC108181437 Neighboring gene formin-like 3 Neighboring gene somatostatin receptor type 3-like Neighboring gene RNA binding motif, single stranded interacting protein 2b Neighboring gene SUMO specific peptidase 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis. Pi X, et al. Circ Res, 2012 Aug 17. PMID 22777006, Free PMC Article
    2. Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis. Zhai Y, et al. PLoS Genet, 2023 Sep. PMID 37713421, Free PMC Article
    3. CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. Keatinge M, et al. PLoS Genet, 2021 Apr. PMID 33914736, Free PMC Article
    4. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data reveal a novel role for LRP1 in the regulation of Bmp4 signaling by regulating receptor complex endocytosis.
      Title: LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    prolow-density lipoprotein receptor-related protein 1; low-density lipoprotein receptor-related protein 1
    Names
    low density lipoprotein receptor-related protein 1
    low density lipoprotein receptor-related protein 1b

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      25451559..25687368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162219.5 → XP_005162276.1  low-density lipoprotein receptor-related protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B922, F1QY34
      Related
      ENSDARP00000082641.5, ENSDART00000088208.6
      Conserved Domains (12) summary
      smart00192
      Location:2738 → 2769
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:3097 → 3139
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:2985 → 3019
      EGF_CA; Calcium-binding EGF-like domain
      COG3386
      Location:2236 → 2464
      YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
      cd00112
      Location:3578 → 3612
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:292 → 325
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:2861 → 2895
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:4020 → 4060
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam12662
      Location:2965 → 2988
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:811 → 846
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00104
      Location:2523 → 2559
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl18310
      Location:292 → 479
      NHL; NHL repeat unit of beta-propeller proteins

    2. XM_021469971.2 → XP_021325646.1  low-density lipoprotein receptor-related protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PTJ2
      Conserved Domains (12) summary
      smart00192
      Location:2738 → 2769
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:3097 → 3139
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:2985 → 3019
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:3578 → 3612
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:292 → 325
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:2861 → 2895
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:4020 → 4060
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl00104
      Location:2523 → 2559
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl18310
      Location:292 → 479
      NHL; NHL repeat unit of beta-propeller proteins
      pfam12662
      Location:2965 → 2988
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:811 → 846
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl26742
      Location:2236 → 2464
      SGL; SMP-30/Gluconolaconase/LRE-like region

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395153.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      19559..116329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473697.2 → XP_021329372.1  low-density lipoprotein receptor-related protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PE34
      Conserved Domains (3) summary
      smart00192
      Location:36 → 69
      LDLa; Low-density lipoprotein receptor domain class A
      cd00112
      Location:82 → 114
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:170 → 198
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.