neu3.2 sialidase 3 (membrane sialidase), tandem duplicate 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: neu3.2provided by ZNC
Official Full Name: sialidase 3 (membrane sialidase), tandem duplicate 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-262
See related: Ensembl:ENSDARG00000010047 AllianceGenome:ZFIN:ZDB-GENE-040801-262
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:6912336; zgc:100806
Summary: Enables exo-alpha-sialidase activity. Predicted to be involved in ganglioside catabolic process and oligosaccharide catabolic process. Predicted to act upstream of or within lipid catabolic process. Located in cytosol. Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Orthologous to human NEU3 (neuraminidase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (21796710..21799292)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (21760074..21762656)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of Zebrafish Cytosolic Sialidase Neu3.2 Affects Skeletal Muscle Development.
Title: Downregulation of Zebrafish Cytosolic Sialidase Neu3.2 Affects Skeletal Muscle Development.
Characterization of three sialidases from Danio rerio.
Title: Characterization of three sialidases from Danio rerio.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables exo-alpha-sialidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables exo-alpha-sialidase activity	IDA Inferred from Direct Assay more info	PubMed
enables exo-alpha-sialidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ganglioside catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in oligosaccharide catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sialidase-3.2

Names: sialidase 3, tandem duplicate 2; sialidase 3.2

NP_001003644.2

EC 3.2.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.