nr2f1b nuclear receptor subfamily 2, group F, member 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nr2f1bprovided by ZNC
Official Full Name: nuclear receptor subfamily 2, group F, member 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1438
See related: Ensembl:ENSDARG00000017168 AllianceGenome:ZFIN:ZDB-GENE-040426-1438
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nr2f1l; zgc:65854; zgc:77353
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in angioblast cell migration. Acts upstream of or within venous blood vessel development. Predicted to be located in nucleus. Is expressed in several structures, including basal plate midbrain region; midbrain neural keel; nervous system; pharyngeal arch; and vasculature. Human ortholog(s) of this gene implicated in Bosch-Boonstra-Schaaf optic atrophy syndrome. Orthologous to human NR2F1 (nuclear receptor subfamily 2 group F member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (43797146..43808197)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (43950349..43961400)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of nr2f genes in brain regionalization and eye development during early zebrafish development.
Title: Involvement of nr2f genes in brain regionalization and eye development during early zebrafish development.
Interaction of transcription factors Islet2 and Nr2f1b to control vascular patterning during zebrafish development.
Title: Interaction of transcription factors Islet2 and Nr2f1b to control vascular patterning during zebrafish development.
nr2f1b control venous specification and angiogenic patterning during zebrafish vascular development, which is mediated by Notch signalings.
Title: Nr2f1b control venous specification and angiogenic patterning during zebrafish vascular development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angioblast cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cranial skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within venous blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear receptor subfamily 2 group F member 1-B

Names: COUPTFalpha-B; nuclear receptor subfamily 2, group F, member 1, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200592.1 → NP_956886.1 nuclear receptor subfamily 2 group F member 1-B

See identical proteins and their annotated locations for NP_956886.1

Status: PROVISIONAL

Source sequence(s)

BC056748

UniProtKB/Swiss-Prot

Q6P0E6, Q6PH18

UniProtKB/TrEMBL

A0A8M9QGF2

Related

ENSDARP00000010118.5, ENSDART00000027242.6

Conserved Domains (2) summary

cd06948
Location:152 → 387

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family

cd06958
Location:54 → 126

NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers