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    rnaseh1 ribonuclease H1 [ Danio rerio (zebrafish) ]

    Gene ID: 436932, updated on 4-Jan-2025

    Summary

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    Official Symbol
    rnaseh1provided by ZNC
    Official Full Name
    ribonuclease H1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-407
    See related
    Ensembl:ENSDARG00000042571 AllianceGenome:ZFIN:ZDB-GENE-040718-407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:91971
    Summary
    Predicted to enable RNA-DNA hybrid ribonuclease activity; magnesium ion binding activity; and nucleic acid binding activity. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 2. Orthologous to human RNASEH1 (ribonuclease H1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See rnaseh1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (30378858..30385570)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (30475979..30482691)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene ribosomal protein S7 Neighboring gene myelin transcription factor 1-like, a Neighboring gene centrosomal protein 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RNaseH-mediated simultaneous piggyback knockdown of multiple genes in adult zebrafish. Raman R, et al. Sci Rep, 2020 Nov 19. PMID 33214638, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease H1
    NP_001002659.2
    NP_001272757.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002659.2 → NP_001002659.2  ribonuclease H1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC076457, EH542009
      UniProtKB/TrEMBL
      A0A8M1N0V4
      Related
      ENSDARP00000062440.3, ENSDART00000062441.5
      Conserved Domains (3) summary
      COG3341
      Location:22 → 272
      Rnh1; RNase HI-related protein, contains viroplasmin and RNaseH domains [General function prediction only]
      cd09280
      Location:152 → 293
      RNase_HI_eukaryote_like; Eukaryotic RNase H is essential and is longer and more complex than their prokaryotic counterparts
      pfam01693
      Location:30 → 71
      Cauli_VI; Caulimovirus viroplasmin

    2. NM_001285828.1 → NP_001272757.1  ribonuclease H1 isoform 2

      See identical proteins and their annotated locations for NP_001272757.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 5' region, which results in a downstream translation start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC076457, EH544014
      UniProtKB/TrEMBL
      B2GQ70, Q6DG94
      Related
      ENSDARP00000140924.1, ENSDART00000169140.3
      Conserved Domains (2) summary
      cd09280
      Location:131 → 272
      RNase_HI_eukaryote_like; Eukaryotic RNase H is essential and is longer and more complex than their prokaryotic counterparts
      pfam01693
      Location:9 → 50
      Cauli_VI; Caulimovirus viroplasmin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      30378858..30385570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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