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    crebbpa CREB binding protein a [ Danio rerio (zebrafish) ]

    Gene ID: 566841, updated on 27-Dec-2024

    Summary

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    Official Symbol
    crebbpaprovided by ZNC
    Official Full Name
    CREB binding protein aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050208-439
    See related
    Ensembl:ENSDARG00000104609 AllianceGenome:ZFIN:ZDB-GENE-050208-439
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cbp-b; crebbp; si:dkey-206l1.6; si:dkey-44g23.1
    Summary
    Predicted to enable several functions, including histone acetyltransferase activity; transcription coactivator activity; and zinc ion binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including blastoderm; blastodisc; digestive system; segmental plate; and solid lens vesicle. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See crebbpa in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (26702784..26790743)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (26840341..26928291)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene wu:fc22b06 Neighboring gene adenylate cyclase 9 Neighboring gene serine/threonine-protein kinase pim-2 Neighboring gene SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Directional divergence of Ep300 duplicates in teleosts and its implications. Wang X, et al. BMC Evol Biol, 2020 Oct 31. PMID 33129255, Free PMC Article
    2. Development and validation of chemical kindling in adult zebrafish: A simple and improved chronic model for screening of antiepileptic agents. Kumari S, et al. J Neurosci Methods, 2020 Dec 1. PMID 32818549
    3. Embelin Protects Against Acute Pentylenetetrazole-Induced Seizures and Positively Modulates Cognitive Function in Adult Zebrafish. Kundap UP, et al. Front Pharmacol, 2019. PMID 31708779, Free PMC Article
    4. Zebrafish as a Model for Epilepsy-Induced Cognitive Dysfunction: A Pharmacological, Biochemical and Behavioral Approach. Kundap UP, et al. Front Pharmacol, 2017. PMID 28824436, Free PMC Article
    5. Effect of newer anti-epileptic drugs (AEDs) on the cognitive status in pentylenetetrazol induced seizures in a zebrafish model. Choo BKM, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2019 Jun 8. PMID 30844417

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CREB-binding protein
    Names
    CREB binding protein (Rubinstein-Taybi syndrome)
    CREBBPb
    XP_005161826.1
    XP_005161827.1
    XP_005161828.1
    XP_021329191.1
    XP_021329192.1
    XP_021329193.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      26702784..26790743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161769.5 → XP_005161826.1  CREB-binding protein isoform X1

      UniProtKB/TrEMBL
      A0A8M2B8L6
      Related
      ENSDARP00000137457.1, ENSDART00000158756.2
      Conserved Domains (11) summary
      cd05495
      Location:980 → 1087
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      PHA03193
      Location:751 → 919
      PHA03193; tegument protein VP11/12; Provisional
      smart00551
      Location:1659 → 1737
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:1598 → 1638
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      pfam09606
      Location:1902 → 2333
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15802
      Location:1099 → 1171
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15647
      Location:1172 → 1206
      PHD_CBP; PHD finger found in CREB-binding protein (CBP)
      pfam02135
      Location:325 → 392
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:548 → 628
      KIX; KIX domain
      pfam08214
      Location:1235 → 1542
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:1957 → 2043
      Creb_binding; Creb binding

    2. XM_005161770.5 → XP_005161827.1  CREB-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A0R4IPF2, A0A8M2B8J6
      Related
      ENSDARP00000135614.1, ENSDART00000166775.3
      Conserved Domains (10) summary
      cd05495
      Location:979 → 1086
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:1658 → 1736
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:1597 → 1637
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      pfam09606
      Location:1901 → 2332
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15802
      Location:1098 → 1170
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15647
      Location:1171 → 1205
      PHD_CBP; PHD finger found in CREB-binding protein (CBP)
      pfam02135
      Location:325 → 392
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:548 → 628
      KIX; KIX domain
      pfam08214
      Location:1234 → 1541
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:1956 → 2042
      Creb_binding; Creb binding

    3. XM_005161771.5 → XP_005161828.1  CREB-binding protein isoform X3

      UniProtKB/TrEMBL
      A0A2R8Q4T2, A0A8M2B8N6
      Related
      ENSDARP00000147838.1, ENSDART00000187997.1
      Conserved Domains (11) summary
      cd05495
      Location:897 → 1004
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:1576 → 1654
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:1515 → 1555
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      pfam09606
      Location:1819 → 2250
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15802
      Location:1016 → 1088
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15647
      Location:1089 → 1123
      PHD_CBP; PHD finger found in CREB-binding protein (CBP)
      pfam02135
      Location:325 → 392
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:548 → 628
      KIX; KIX domain
      pfam03153
      Location:635 → 837
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam08214
      Location:1152 → 1459
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:1874 → 1960
      Creb_binding; Creb binding

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395113.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      7723..60810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473516.1 → XP_021329191.1  CREB-binding protein isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q3D9
      Conserved Domains (12) summary
      cd05495
      Location:980 → 1087
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      cd02337
      Location:1598 → 1638
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:1099 → 1171
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15647
      Location:1172 → 1206
      PHD_CBP; PHD finger found in CREB-binding protein (CBP)
      pfam02172
      Location:548 → 628
      KIX; KIX domain
      pfam02135
      Location:325 → 392
      zf-TAZ; TAZ zinc finger
      pfam08214
      Location:1235 → 1542
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:1956 → 2044
      Creb_binding; Creb binding
      pfam09606
      Location:1877 → 2330
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl26464
      Location:1758 → 1841
      Atrophin-1; Atrophin-1 family
      cl27975
      Location:653 → 895
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
      cl28295
      Location:784 → 988
      PKS_KS; Beta-ketoacyl synthase

    2. XM_021473517.1 → XP_021329192.1  CREB-binding protein isoform X5

      UniProtKB/TrEMBL
      A0A8M9PDM0
      Conserved Domains (11) summary
      cd05495
      Location:979 → 1086
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      cd02337
      Location:1597 → 1637
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:1098 → 1170
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15647
      Location:1171 → 1205
      PHD_CBP; PHD finger found in CREB-binding protein (CBP)
      pfam02172
      Location:548 → 628
      KIX; KIX domain
      pfam02135
      Location:325 → 392
      zf-TAZ; TAZ zinc finger
      pfam08214
      Location:1234 → 1541
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:1955 → 2043
      Creb_binding; Creb binding
      pfam09606
      Location:1876 → 2329
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25496
      Location:642 → 912
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl26464
      Location:1757 → 1840
      Atrophin-1; Atrophin-1 family

    3. XM_021473518.1 → XP_021329193.1  CREB-binding protein isoform X6

      UniProtKB/TrEMBL
      A0A8M9PQB0
      Conserved Domains (11) summary
      cd05495
      Location:897 → 1004
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      cd02337
      Location:1515 → 1555
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:1016 → 1088
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15647
      Location:1089 → 1123
      PHD_CBP; PHD finger found in CREB-binding protein (CBP)
      pfam02172
      Location:548 → 628
      KIX; KIX domain
      pfam02135
      Location:325 → 392
      zf-TAZ; TAZ zinc finger
      pfam08214
      Location:1152 → 1459
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:1873 → 1961
      Creb_binding; Creb binding
      pfam09606
      Location:1794 → 2247
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25751
      Location:751 → 897
      DUF4045; Domain of unknown function (DUF4045)
      cl26464
      Location:1675 → 1758
      Atrophin-1; Atrophin-1 family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001089455.2: Suppressed sequence

      Description
      NM_001089455.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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