mms19 MMS19 homolog, cytosolic iron-sulfur assembly component [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mms19provided by ZNC
Official Full Name: MMS19 homolog, cytosolic iron-sulfur assembly componentprovided by ZNC
Primary source: ZFIN:ZDB-GENE-120316-2
See related: Ensembl:ENSDARG00000079067 AllianceGenome:ZFIN:ZDB-GENE-120316-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to be involved in protein maturation by iron-sulfur cluster transfer. Predicted to act upstream of or within DNA damage response. Predicted to be located in cytoplasm. Predicted to be part of MMXD complex and cytosolic [4Fe-4S] assembly targeting complex. Orthologous to human MMS19 (MMS19 homolog, cytosolic iron-sulfur assembly component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (2804523..2850332)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (2769789..2813691)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders.
Title: CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in protein maturation by iron-sulfur cluster transfer	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein maturation by iron-sulfur cluster transfer	IEA Inferred from Electronic Annotation more info
involved_in protein maturation by iron-sulfur cluster transfer	IEA Inferred from Electronic Annotation more info
involved_in protein maturation by iron-sulfur cluster transfer	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of MMXD complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of cytosolic [4Fe-4S] assembly targeting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic [4Fe-4S] assembly targeting complex	IEA Inferred from Electronic Annotation more info
part_of cytosolic [4Fe-4S] assembly targeting complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: MMS19 nucleotide excision repair protein homolog

Names: MMS19-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347662.1 → NP_001334591.1 MMS19 nucleotide excision repair protein homolog

Status: VALIDATED

Source sequence(s)

CU459170, CU459184

UniProtKB/Swiss-Prot

E7FBU4

UniProtKB/TrEMBL

A0A8M2B1Z5, R4GEM8

Related

ENSDARP00000126941.1, ENSDART00000152193.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

2804523..2850332

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005155991.4 → XP_005156048.1 MMS19 nucleotide excision repair protein homolog isoform X1

See identical proteins and their annotated locations for XP_005156048.1

UniProtKB/Swiss-Prot

E7FBU4

UniProtKB/TrEMBL

A0A8M2B1Z5, R4GEM8

Conserved Domains (2) summary

pfam12460
Location:526 → 947

MMS19_C; RNAPII transcription regulator C-terminal

pfam14500
Location:45 → 303

MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II