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    klf9 Kruppel like factor 9 [ Danio rerio (zebrafish) ]

    Gene ID: 565869, updated on 9-Dec-2024

    Summary

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    Official Symbol
    klf9provided by ZNC
    Official Full Name
    Kruppel like factor 9provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060526-244
    See related
    Ensembl:ENSDARG00000068194 AllianceGenome:ZFIN:ZDB-GENE-060526-244
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-201c13.3
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Acts upstream of or within T cell proliferation; erythrocyte maturation; and regulation of oxygen metabolic process. Is expressed in forebrain; hindbrain; and midbrain. Orthologous to human KLF9 (KLF transcription factor 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See klf9 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (26075287..26078122)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (25475134..25477969)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 3 Neighboring gene uncharacterized LOC137495591 Neighboring gene microRNA 204-1 Neighboring gene si:ch211-214j8.15 Neighboring gene family with sequence similarity 219 member Ab

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Glucocorticoid-Responsive Transcription Factor Krüppel-Like Factor 9 Regulates fkbp5 and Metabolism. Gans IM, et al. Front Cell Dev Biol, 2021. PMID 34692682, Free PMC Article
    2. Chronic cortisol exposure in early development leads to neuroendocrine dysregulation in adulthood. Hartig EI, et al. BMC Res Notes, 2020 Aug 3. PMID 32746894, Free PMC Article
    3. Decreased thyroid hormone signaling accelerates the reinnervation of the optic tectum following optic nerve crush in adult zebrafish. Bhumika S, et al. Mol Cell Neurosci, 2015 Sep. PMID 25913150
    4. Acute exposure to ustiloxin A affects growth and development of early life zebrafish, Danio rerio. Hu Z, et al. Chemosphere, 2019 Jul. PMID 30978596
    5. Investigation of NH3 as a selective thyroid hormone receptor modulator in larval zebrafish (Danio rerio). Walter KM, et al. Neurotoxicology, 2021 May. PMID 33745965, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Kruppel-like factor 9 deregulates both physiological gene expression and development.
      Title: Loss of Krüppel-like factor 9 deregulates both physiological gene expression and development.
    2. Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity.
      Title: Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity.
    3. knockdown of klf9 in zebrafish embryos impaired hematopoietic development including erythroid maturation and T lymphopoiesis
      Title: Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within erythrocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of oxygen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Krueppel-like factor 9
    Names
    BTEB

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128729.1 → NP_001122201.1  Krueppel-like factor 9

      See identical proteins and their annotated locations for NP_001122201.1

      Status: PROVISIONAL

      Source sequence(s)
      BC163222
      UniProtKB/TrEMBL
      A2BGS7, B3DIR3
      Related
      ENSDARP00000089244.3, ENSDART00000098473.4
      Conserved Domains (4) summary
      COG5048
      Location:113 → 161
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:101 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:159 → 181
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 168
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      26075287..26078122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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