pgls 6-phosphogluconolactonase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pglsprovided by ZNC
Official Full Name: 6-phosphogluconolactonaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040822-9
See related: Ensembl:ENSDARG00000021233 AllianceGenome:ZFIN:ZDB-GENE-040822-9
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb11g07; wu:fb11g07; zgc:100853
Summary: Predicted to enable 6-phosphogluconolactonase activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Predicted to act upstream of or within pentose-phosphate shunt. Predicted to be active in cytosol. Orthologous to human PGLS (6-phosphogluconolactonase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (52684556..52700610)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (52429893..52445947)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb11g07.x1 (e-PCR)
- UniSTS:190052

fb11g07.x1 (e-PCR)
- UniSTS:190053

AI384418 (e-PCR)
- UniSTS:206729

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 6-phosphogluconolactonase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 6-phosphogluconolactonase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pentose-phosphate shunt	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt, oxidative branch	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 6-phosphogluconolactonase

NP_001004117.2

EC 3.1.1.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004117.3 → NP_001004117.2 6-phosphogluconolactonase

Status: VALIDATED

Source sequence(s)

AL840631

UniProtKB/TrEMBL

A0A8M1N1S8, F1R0C0

Related

ENSDARP00000113038.1, ENSDART00000139037.2

Conserved Domains (1) summary

cd01400
Location:14 → 233

6PGL; 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard ...