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    vrk2 VRK serine/threonine kinase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 394145, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vrk2provided by ZNC
    Official Full Name
    VRK serine/threonine kinase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1046
    See related
    Ensembl:ENSDARG00000021547 AllianceGenome:ZFIN:ZDB-GENE-040426-1046
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    vrk; zgc:56483
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within aggressive behavior and social behavior. Predicted to be located in membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human VRK2 (VRK serine/threonine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See vrk2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (26780004..26799235, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (26649550..26668785, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487401 Neighboring gene si:rp71-1h3.1 Neighboring gene FA complementation group L Neighboring gene coiled-coil domain containing 85A Neighboring gene heme-binding protein soul2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Behavioral and neurological effects of Vrk1 deficiency in zebrafish. Carrasco Apolinario ME, et al. Biochem Biophys Res Commun, 2023 Oct 1. PMID 37429068
    2. Vrk2 deficiency elicits aggressive behavior in female zebrafish. Umeda R, et al. Genes Cells, 2022 Apr. PMID 35094457
    3. Identifying candidate genes for 2p15p16.1 microdeletion syndrome using clinical, genomic, and functional analysis. Bagheri H, et al. JCI Insight, 2016 Mar 17. PMID 27699255, Free PMC Article
    4. The Fanconi anemia gene network is conserved from zebrafish to human. Titus TA, et al. Gene, 2006 Apr 26. PMID 16515849
    5. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vrk2 deficiency elicits aggressive behavior in female zebrafish.
      Title: Vrk2 deficiency elicits aggressive behavior in female zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56483

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within social behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase VRK2
    Names
    vaccinia related kinase 2
    NP_957464.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201170.2 → NP_957464.2  serine/threonine-protein kinase VRK2

      Status: VALIDATED

      Source sequence(s)
      CR354594, EH589503
      UniProtKB/TrEMBL
      A0A8M1PE59, A0A8M6Z1N2, B8JHS7
      Related
      ENSDARP00000038349.7, ENSDART00000036419.9
      Conserved Domains (2) summary
      COG0515
      Location:25 → 406
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14123
      Location:13 → 313
      STKc_VRK2; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      26780004..26799235 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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