stat5a signal transducer and activator of transcription 5a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: stat5aprovided by ZNC
Official Full Name: signal transducer and activator of transcription 5aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030820-2
See related: Ensembl:ENSDARG00000019392 AllianceGenome:ZFIN:ZDB-GENE-030820-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Stat5; stat5; stat5b; stat5.1; sb:eu615
Summary: Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway via JAK-STAT; hemopoiesis; and regulation of hemopoiesis. Predicted to be located in cytosol. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Is expressed in adaxial cell; female organism; liver; and telencephalon. Used to study growth hormone insensitivity syndrome with immune dysregulation 1. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; growth hormone insensitivity syndrome with immune dysregulation 1; and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (17129269..17523328)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (16979476..17182373)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of Potential Non-Canonical or Alternate STAT5 Functions in Immune Development and Growth.
Title: Analysis of Potential Non-Canonical or Alternate STAT5 Functions in Immune Development and Growth.
Essential roles of stat5.1/stat5b in controlling fish somatic growth
Title: Essential roles of stat5.1/stat5b in controlling fish somatic growth.
This study indicates that CISH functions as a conserved in vivo target and regulator of STAT5 in the control of embryonic hematopoiesis.
Title: Regulation of embryonic hematopoiesis by a cytokine-inducible SH2 domain homolog in zebrafish.
study demonstrates that STAT5 in basophils is activated through both the IL-3 and the FcepsilonRI signaling pathway
Title: STAT5 in human basophils: IL-3 is required for its FcεRI-mediated phosphorylation.
Studies demonstrate a conserved role for SOCS1 in T cell development and suggest a novel T cell-independent function in embryonic myelopoiesis mediated, at least in part, via its effects on receptors using the Jak2-Stat5 pathway.
Title: Suppressor of cytokine signaling 1 regulates embryonic myelopoiesis independently of its effects on T cell development.
The stat5.1 gene lies next to the stat3 gene.
Title: Conservation, duplication and divergence of the zebrafish stat5 genes.

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General gene information

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Markers

G46664 (e-PCR)
- UniSTS:107464

Z6566 (e-PCR)
- UniSTS:34800

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelium development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lymphocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of lymphocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: signal transducer and activator of transcription 5A

Names: signal transducer and activator of transcription 5.1; signal transducer and activator of transcription 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194387.2 → NP_919368.2 signal transducer and activator of transcription 5A

See identical proteins and their annotated locations for NP_919368.2

Status: PROVISIONAL

Source sequence(s)

AY501426

UniProtKB/TrEMBL

A0A2R8QIU2, F6P3K1, Q68SP3

Related

ENSDARP00000022542.6, ENSDART00000024832.8

Conserved Domains (4) summary

pfam01017
Location:141 → 330

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:332 → 582

STAT_bind; STAT protein, DNA binding domain

pfam02865
Location:2 → 124

STAT_int; STAT protein, protein interaction domain

cl15255
Location:573 → 710

SH2; Src homology 2 (SH2) domain