mcu mitochondrial calcium uniporter [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mcuprovided by ZNC
Official Full Name: mitochondrial calcium uniporterprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061013-24
See related: Ensembl:ENSDARG00000101175 AllianceGenome:ZFIN:ZDB-GENE-061013-24
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ccdc109a; wu:fi24a01; zgc:153607
Summary: Enables identical protein binding activity. Acts upstream of or within several processes, including calcium import into the mitochondrion; convergent extension involved in gastrulation; and mitochondrial calcium ion homeostasis. Predicted to be located in mitochondrial inner membrane. Predicted to be part of uniplex complex. Is expressed in brain; head; liver; pericardial region; and visceral fat. Used to study cardiomyopathy. Orthologous to human MCU (mitochondrial calcium uniporter). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (4721644..4848889, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (4593058..4720303, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cryo-electron microscopy reconstructions of MCU channels from zebrafish and Cyphellophora europaea at 8.5 A and 3.2 A resolutions, respectively
Title: Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters.
Genetic and pharmacological inactivation of MCU prevents dopaminergic neuronal cell loss in pink1Y431* mutant zebrafish.
Title: Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1(-/-) zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

G47296 (e-PCR)
- UniSTS:108078

G47376 (e-PCR)
- UniSTS:108157

fi24a01.x1 (e-PCR)
- UniSTS:197073

Z9564 (e-PCR)
- UniSTS:77782

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables uniporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables uniporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium import into the mitochondrion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium import into the mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium import into the mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein complex oligomerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of heart contraction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of calcium channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of uniplex complex	IBA Inferred from Biological aspect of Ancestor more info
part_of uniplex complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calcium uniporter protein, mitochondrial

Names: coiled-coil domain-containing protein 109A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.