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    dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 100141364, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dyrk3provided by ZNC
    Official Full Name
    dual specificity tyrosine phosphorylation regulated kinase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080219-31
    See related
    Ensembl:ENSDARG00000070600 AllianceGenome:ZFIN:ZDB-GENE-080219-31
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dyrk2; zgc:172180
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within muscle cell development. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Is expressed in adaxial cell and somite. Orthologous to human DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dyrk3 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (21259358..21267552, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (21101019..21106306, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene MAPK activated protein kinase 2a Neighboring gene interleukin 10 Neighboring gene Ras association domain family member 5 Neighboring gene uncharacterized LOC137490705 Neighboring gene inhibitor of nuclear factor kappa B kinase subunit epsilon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. DYRK2 displays muscle fiber type specific function during zebrafish early somitogenesis. Sun W, et al. Int J Dev Biol, 2017. PMID 28695966
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell cycle G2/M phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress granule disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 3
    NP_001108400.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114928.2 → NP_001108400.2  dual specificity tyrosine-phosphorylation-regulated kinase 3

      Status: VALIDATED

      Source sequence(s)
      CT573238
      UniProtKB/TrEMBL
      A0A8M1NGE5, A9JRD5
      Related
      ENSDARP00000106736.1, ENSDART00000128681.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      21259358..21267552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394817.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      103585..111794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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