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    hbegfb heparin-binding EGF-like growth factor b [ Danio rerio (zebrafish) ]

    Gene ID: 407664, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hbegfbprovided by ZNC
    Official Full Name
    heparin-binding EGF-like growth factor bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070820-6
    See related
    Ensembl:ENSDARG00000031246 AllianceGenome:ZFIN:ZDB-GENE-070820-6
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hbegf; zgc:165443
    Summary
    Predicted to enable epidermal growth factor receptor binding activity and growth factor activity. Acts upstream of or within heart contraction. Predicted to be located in membrane. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hbegfb in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (30161295..30168949, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (30124603..30132261, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 23 member 1 Neighboring gene prefoldin subunit 1 Neighboring gene heterogeneous nuclear ribonucleoprotein H1, like Neighboring gene uncharacterized LOC137488826

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. HB-EGF promotes progenitor cell proliferation and sensory neuron regeneration in the zebrafish olfactory epithelium. Sireci S, et al. FEBS J, 2024 May. PMID 38088047
    2. Differential regulation of betacellulin and heparin-binding EGF-like growth factor in cultured zebrafish ovarian follicle cells by EGF family ligands. Tse AC, et al. Comp Biochem Physiol A Mol Integr Physiol, 2009 May. PMID 19000772
    3. Lineage-specific co-evolution of the Egf receptor/ligand signaling system. Laisney JA, et al. BMC Evol Biol, 2010 Jan 27. PMID 20105326, Free PMC Article
    4. Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration. Schall KA, et al. Am J Physiol Gastrointest Liver Physiol, 2015 Aug 1. PMID 26089336, Free PMC Article
    5. Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer. Cigliola V, et al. Nat Commun, 2023 Aug 11. PMID 37567873, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HB-EGF promotes progenitor cell proliferation and sensory neuron regeneration in the zebrafish olfactory epithelium.
      Title: HB-EGF promotes progenitor cell proliferation and sensory neuron regeneration in the zebrafish olfactory epithelium.
    2. These results suggest that there is an EGF signaling network in the zebrafish ovarian follicle, and the functionality of this network is self-regulated by its own members.
      Title: Differential regulation of betacellulin and heparin-binding EGF-like growth factor in cultured zebrafish ovarian follicle cells by EGF family ligands.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heparin-binding EGF-like growth factor b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100401.2 → NP_001093871.2  heparin-binding EGF-like growth factor b precursor

      Status: VALIDATED

      Source sequence(s)
      BX510945, EH542909, EH548388, EH569504
      UniProtKB/TrEMBL
      A0A8M1NE67
      Related
      ENSDARP00000152981.1, ENSDART00000193171.1
      Conserved Domains (1) summary
      PHA02887
      Location:123 → 163
      PHA02887; EGF-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      30161295..30168949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161297.5 → XP_005161354.1  heparin-binding EGF-like growth factor b isoform X1

      UniProtKB/TrEMBL
      A0A8M2B880
      Related
      ENSDARP00000109242.2, ENSDART00000130820.4
      Conserved Domains (1) summary
      PHA02887
      Location:123 → 163
      PHA02887; EGF-like protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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