rhot2 ras homolog family member T2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rhot2provided by ZNC
Official Full Name: ras homolog family member T2provided by ZNC
Primary source: ZFIN:ZDB-GENE-051120-96
See related: Ensembl:ENSDARG00000056328 AllianceGenome:ZFIN:ZDB-GENE-051120-96
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: miro2; zgc:123249
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in cellular homeostasis; mitochondrial outer membrane permeabilization; and mitochondrion transport along microtubule. Predicted to act upstream of or within small GTPase-mediated signal transduction. Located in mitochondrion. Is expressed in female organism; fin bud; midbrain; muscle; and somite. Orthologous to human RHOT2 (ras homolog family member T2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (37533728..37559496)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (37646008..37671408)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial outer membrane permeabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion transport along microtubule	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitochondrial Rho GTPase 2

Names: MIRO-2; ras homolog gene family, member T2

NP_001032768.1

EC 3.6.5.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037679.2 → NP_001032768.1 mitochondrial Rho GTPase 2

See identical proteins and their annotated locations for NP_001032768.1

Status: VALIDATED

Source sequence(s)

CU571252

UniProtKB/Swiss-Prot

Q32LU1

Related

ENSDARP00000061202.5, ENSDART00000061203.6

Conserved Domains (5) summary

smart00174
Location:7 → 169

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cd01892
Location:415 → 591

Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal

cd01893
Location:3 → 169

Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal

pfam08355
Location:341 → 409

EF_assoc_1; EF hand associated

pfam08356
Location:221 → 301

EF_assoc_2; EF hand associated