mettl6 methyltransferase 6, methylcytidine [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mettl6provided by ZNC
Official Full Name: methyltransferase 6, methylcytidineprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-926
See related: Ensembl:ENSDARG00000070085 AllianceGenome:ZFIN:ZDB-GENE-040426-926
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56175; zgc:76943
Summary: Predicted to enable RNA methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity. Predicted to act upstream of or within methylation and tRNA processing. Orthologous to human METTL6 (methyltransferase 6, tRNA N3-cytidine). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (40340514..40344223)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (40390518..40394188)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fa13e08.s1 (e-PCR)
- UniSTS:202363

fd06f05.x1 (e-PCR)
- UniSTS:195001

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables S-adenosylmethionine-dependent methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA N(3)-methylcytidine methyltransferase METTL6

Names: methyltransferase like 6

NP_956497.2

EC 2.1.1.-

XP_068070123.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200203.2 → NP_956497.2 tRNA N(3)-methylcytidine methyltransferase METTL6

See identical proteins and their annotated locations for NP_956497.2

Status: PROVISIONAL

Source sequence(s)

BC066749

UniProtKB/TrEMBL

Q6NY40

Related

ENSDARP00000093347.3, ENSDART00000102571.4

Conserved Domains (3) summary

COG0500
Location:71 → 261

SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

pfam08242
Location:98 → 199

Methyltransf_12; Methyltransferase domain

cl17173
Location:164 → 250

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...