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    gtf2h5 general transcription factor IIH, polypeptide 5 [ Danio rerio (zebrafish) ]

    Gene ID: 751713, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gtf2h5provided by ZNC
    Official Full Name
    general transcription factor IIH, polypeptide 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041001-144
    See related
    Ensembl:ENSDARG00000056099 AllianceGenome:ZFIN:ZDB-GENE-041001-144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153434; si:dkey-12h9.4
    Summary
    Predicted to be involved in nucleotide-excision repair, preincision complex assembly and transcription by RNA polymerase II. Predicted to act upstream of or within nucleotide-excision repair. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. Human ortholog(s) of this gene implicated in photosensitive trichothiodystrophy 3. Orthologous to human GTF2H5 (general transcription factor IIH subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gtf2h5 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (26045253..26047792, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (26146163..26148702, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding protein 1 Neighboring gene si:dkey-12h9.6 Neighboring gene serine active site containing 1 Neighboring gene myc target 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary conservation of TFIIH subunits: implications for the use of zebrafish as a model to study TFIIH function and regulation. Silva IA, et al. Comp Biochem Physiol B Biochem Mol Biol, 2014 Jun-Jul. PMID 24731924
    2. Expressed sequence tag analysis of expression profiles of zebrafish testis and ovary. Zeng S, et al. Gene, 2002 Jul 10. PMID 12234666
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC153434

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair, preincision complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor IIH subunit 5
    Names
    ttda

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134362.2 → NP_001127834.2  general transcription factor IIH subunit 5

      See identical proteins and their annotated locations for NP_001127834.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL954831, BI709501, EH536442
      UniProtKB/TrEMBL
      A0A8M1NLI1, Q5SNQ6
      Related
      ENSDARP00000126549.1, ENSDART00000151874.2
      Conserved Domains (1) summary
      pfam06331
      Location:1 → 69
      Tfb5; Transcription factor TFIIH complex subunit Tfb5

    2. NM_001243148.1 → NP_001230077.1  general transcription factor IIH subunit 5

      See identical proteins and their annotated locations for NP_001230077.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL954831, BI709501, EH551506
      UniProtKB/TrEMBL
      A0A8M1NLI1, Q5SNQ6
      Related
      ENSDARP00000072996.5, ENSDART00000078535.7
      Conserved Domains (1) summary
      pfam06331
      Location:1 → 69
      Tfb5; Transcription factor TFIIH complex subunit Tfb5

    3. NM_001302744.1 → NP_001289673.1  general transcription factor IIH subunit 5

      See identical proteins and their annotated locations for NP_001289673.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL954831, BI709501, EH583809
      UniProtKB/TrEMBL
      A0A8M1NLI1, Q5SNQ6
      Conserved Domains (1) summary
      pfam06331
      Location:1 → 69
      Tfb5; Transcription factor TFIIH complex subunit Tfb5

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      26045253..26047792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395074.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      160634..163173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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