itpkca inositol-trisphosphate 3-kinase Ca [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: itpkcaprovided by ZNC
Official Full Name: inositol-trisphosphate 3-kinase Caprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6009
See related: Ensembl:ENSDARG00000002994 AllianceGenome:ZFIN:ZDB-GENE-030131-6009
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: itpkc; fi30c01; wu:fi30c01
Summary: Predicted to enable inositol tetrakisphosphate kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Predicted to be involved in inositol phosphate biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human ITPKC (inositol-trisphosphate 3-kinase C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (21279155..21298995)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (21242009..21262359)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fi30c01.x1 (e-PCR)
- UniSTS:197230

AW174919 (e-PCR)
- UniSTS:205797

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables inositol hexakisphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inositol-trisphosphate 3-kinase C

Names: inositol 1,4,5-trisphosphate 3-kinase C; inositol 1,4,5-trisphosphate 3-kinase Ca

XP_686458.2

EC 2.7.1.127

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

21279155..21298995

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_681366.10 → XP_686458.2 inositol-trisphosphate 3-kinase C

UniProtKB/TrEMBL

A0A8N7T5H5, E7F4R8, E9QEW6

Related

ENSDARP00000119462.2, ENSDART00000148346.3

Conserved Domains (1) summary

pfam03770
Location:200 → 411

IPK; Inositol polyphosphate kinase