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    ttyh3b tweety family member 3b [ Danio rerio (zebrafish) ]

    Gene ID: 798421, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ttyh3bprovided by ZNC
    Official Full Name
    tweety family member 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051120-105
    See related
    Ensembl:ENSDARG00000007678 AllianceGenome:ZFIN:ZDB-GENE-051120-105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ttyh3; fj56f11; wu:fj56f11; zgc:123242
    Summary
    Predicted to enable calcium ion binding activity; intracellularly calcium-gated chloride channel activity; and volume-sensitive chloride channel activity. Predicted to be involved in L-glutamate transmembrane transport. Predicted to act upstream of or within chloride transport and monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of chloride channel complex. Predicted to be active in plasma membrane. Orthologous to human TTYH3 (tweety family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ttyh3b in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (11781544..11850368, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (11098845..11163563, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 12b, tandem duplicate 1 Neighboring gene zmp:0000001069 Neighboring gene IQ motif containing E Neighboring gene uncharacterized LOC137495029 Neighboring gene sorting nexin 8b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Hogl S, et al. Proteomics, 2013 May. PMID 23457027
    2. Characterization of paralogous uncx transcription factor encoding genes in zebrafish. Nittoli V, et al. Gene X, 2019 Jun. PMID 31193955, Free PMC Article
    3. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123242

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables volume-sensitive chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables volume-sensitive chloride channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein tweety homolog 3
    Names
    tweety homolog 3b
    volume-regulated anion channel subunit ttyh3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037387.3 → NP_001032464.2  protein tweety homolog 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX569778
      UniProtKB/Swiss-Prot
      Q32LT7
      Related
      ENSDARP00000036553.7, ENSDART00000033361.8

    2. NM_001431093.1 → NP_001418022.1  protein tweety homolog 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX569778
      UniProtKB/TrEMBL
      A0A8M2B6L0

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      11781544..11850368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32LT7.1 GenPept UniProtKB/Swiss-Prot:Q32LT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.