hint1 histidine triad nucleotide binding protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hint1provided by ZNC
Official Full Name: histidine triad nucleotide binding protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040927-8
See related: Ensembl:ENSDARG00000103824 AllianceGenome:ZFIN:ZDB-GENE-040927-8
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:103764
Summary: Predicted to enable hydrolase activity. Predicted to be involved in purine ribonucleotide catabolic process. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Gamstorp-Wohlfart syndrome. Orthologous to human HINT1 (histidine triad nucleotide binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (7636772..7640797)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (7678072..7682097)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in purine ribonucleotide catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adenosine 5'-monophosphoramidase HINT1

NP_001005593.1

EC 3.-.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005593.2 → NP_001005593.1 adenosine 5'-monophosphoramidase HINT1

See identical proteins and their annotated locations for NP_001005593.1

Status: VALIDATED

Source sequence(s)

BX537303

UniProtKB/TrEMBL

B5DDL2, Q642J0

Related

ENSDARP00000133027.1, ENSDART00000160673.2

Conserved Domains (1) summary

cd01276
Location:16 → 118

PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...