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    scrn2 secernin 2 [ Danio rerio (zebrafish) ]

    Gene ID: 558306, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scrn2provided by ZNC
    Official Full Name
    secernin 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040724-75
    See related
    Ensembl:ENSDARG00000043497 AllianceGenome:ZFIN:ZDB-GENE-040724-75
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-184m19.2
    Summary
    Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to act upstream of or within proteolysis. Orthologous to human SCRN2 (secernin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See scrn2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (14635428..14680864, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (14739448..14784917, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:dkey-69c1.1 Neighboring gene uncharacterized LOC137488724 Neighboring gene SUN domain containing ossification factor Neighboring gene uncharacterized LOC101887022

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type exopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    secernin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030116.1 → NP_001025287.1  secernin-2

      See identical proteins and their annotated locations for NP_001025287.1

      Status: PROVISIONAL

      Source sequence(s)
      BX901920
      UniProtKB/Swiss-Prot
      Q5TYS5
      Related
      ENSDARP00000063856.5, ENSDART00000063857.8
      Conserved Domains (1) summary
      cl00467
      Location:7 → 232
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      14635428..14680864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160433.2 → XP_005160490.1  secernin-2 isoform X1

      See identical proteins and their annotated locations for XP_005160490.1

      UniProtKB/Swiss-Prot
      Q5TYS5
      Related
      ENSDARP00000131124.1, ENSDART00000161314.3
      Conserved Domains (1) summary
      cl00467
      Location:7 → 232
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    2. XM_005160434.2 → XP_005160491.1  secernin-2 isoform X1

      See identical proteins and their annotated locations for XP_005160491.1

      UniProtKB/Swiss-Prot
      Q5TYS5
      Conserved Domains (1) summary
      cl00467
      Location:7 → 232
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TYS5.1 GenPept UniProtKB/Swiss-Prot:Q5TYS5

    Gene LinkOut

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