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    haspin histone H3 associated protein kinase [ Danio rerio (zebrafish) ]

    Gene ID: 557879, updated on 9-Dec-2024

    Summary

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    Official Symbol
    haspinprovided by ZNC
    Official Full Name
    histone H3 associated protein kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090313-379
    See related
    Ensembl:ENSDARG00000092290 AllianceGenome:ZFIN:ZDB-GENE-090313-379
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkeyp-26a9.2
    Summary
    Predicted to enable histone H3T3 kinase activity. Predicted to be involved in intracellular signal transduction and mitotic cell cycle. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in brain and otic vesicle. Orthologous to human HASPIN (histone H3 associated protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See haspin in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (23489239..23507710)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (22800207..22816208)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamine (anticodon CUG) Neighboring gene transfer RNA arginine (anticodon CCG) Neighboring gene family with sequence similarity 184 member B Neighboring gene non-SMC condensin I complex, subunit G Neighboring gene ligand dependent nuclear receptor corepressor-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of H3-Thr3 by Haspin Is Required for Primary Cilia Regulation. Quadri R, et al. Int J Mol Sci, 2021 Jul 20. PMID 34299370, Free PMC Article
    2. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase haspin
    XP_017211541.2
    XP_021329574.1
    XP_021330260.2
    XP_021331582.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      23489239..23507710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021475907.2 → XP_021331582.2  serine/threonine-protein kinase haspin

      Related
      ENSDARP00000118059.1, ENSDART00000134576.2

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394481.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      198700..221337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017356052.3 → XP_017211541.2  serine/threonine-protein kinase haspin

      UniProtKB/TrEMBL
      A0A8M6YZ20
      Conserved Domains (1) summary
      cl26373
      Location:773 → 1071
      DUF3635; Domain of unknown function (DUF3635)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395215.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      26782..46190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473899.2 → XP_021329574.1  serine/threonine-protein kinase haspin

      UniProtKB/TrEMBL
      A0A8M9PXH5
      Conserved Domains (1) summary
      cl26373
      Location:773 → 1071
      DUF3635; Domain of unknown function (DUF3635)

    Reference GRCz11 ALT_DRER_TU_3

    Genomic

    1. NW_018395373.1 Reference GRCz11 ALT_DRER_TU_3

      Range
      35773..53050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474585.2 → XP_021330260.2  serine/threonine-protein kinase haspin

    Nucleotide Protein Strain
    Heading Accession and Version

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